{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:49:22Z","timestamp":1791287362928,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T00:00:00Z","timestamp":1340668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report the outcome of 16 children with refractory anaemia with excess of blasts (<jats:styled-content style=\"fixed-case\">RAEB<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a04) and <jats:styled-content style=\"fixed-case\">RAEB<\/jats:styled-content> in transformation (<jats:styled-content style=\"fixed-case\">RAEB<\/jats:styled-content>\u2010T; <jats:italic>n<\/jats:italic>\u00a0=\u00a012) following induction therapy with etoposide, cytarabine and mitoxantrone (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) prior to haematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). The median observation period was 77\u00a0months (range 5\u2013123). Complete remission rate was 81% following induction; no toxic deaths occurred. Eight\u2010year event\u2010free survival and overall survival was 50% and 56%, respectively. None of the three patients with a complex karyotype survived, suggesting karyotype is a crucial prognostic factor for survival. This study indicates the safety and high remission rate of <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> and high survival rates after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for paediatric <jats:styled-content style=\"fixed-case\">RAEB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RAEB<\/jats:styled-content>\u2010T.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09210.x","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T00:37:27Z","timestamp":1340757447000},"page":"657-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcome of children with refractory anaemia with excess of blast (<scp>RAEB<\/scp>) and <scp>RAEB<\/scp> in Transformation (<scp>RAEB<\/scp>\u2010T) in the <scp>J<\/scp>apanese <scp>MDS<\/scp>99 study"],"prefix":"10.1111","volume":"158","author":[{"given":"Akira","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Paediatrics Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Luke's International Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitoshi","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hyogo Medical College Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hiroshima Red Cross Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Okamura","sequence":"additional","affiliation":[{"name":"Section of Paediatrics Kyushu Cancer Centre Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsutoshi","family":"Nakahata","sequence":"additional","affiliation":[{"name":"Institute of iPS cell Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Luke's International Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Japanese Paediatric Myelodysplastic Syndrome (MDS) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400558"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400987"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-280313"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22121"},{"key":"e_1_2_7_6_1","first-page":"1269","article-title":"Intensive chemotherapy in childhood myelodysplastic syndrome. A comparison with results in acute myeloid leukemia","volume":"10","author":"Hasle H.","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.285"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06958.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04361.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402271"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.297"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20944"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.7948"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03369.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.2.434"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2141.2012.09210.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2141.2012.09210.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:26:21Z","timestamp":1695511581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2012.09210.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,26]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1365-2141.2012.09210.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09210.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,26]]},"assertion":[{"value":"2012-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}