{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:02:55Z","timestamp":1784815375101,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Summary<\/jats:title>TRIB<\/jats:styled-content>2<\/jats:italic> is a potent oncogene, elevated in a subset of human acute myeloid leukaemias (AML<\/jats:styled-content>) with a mixed myeloid\/lymphoid phenotype and NOTCH<\/jats:styled-content>1<\/jats:italic> mutations. Although rare in AML<\/jats:styled-content>, activating NOTCH<\/jats:styled-content>1<\/jats:italic> mutations occur in 50% of all T cell acute lymphoblastic leukaemias (T<\/jats:styled-content>\u2010ALL<\/jats:styled-content>). TRIB<\/jats:styled-content>2<\/jats:italic> is a NOTCH<\/jats:styled-content>1<\/jats:italic> target gene that functions in the degradation of key proteins and modulation of MAPK<\/jats:styled-content> signalling pathways, implicated in haematopoietic cell survival and proliferation. This study showed that TRIB<\/jats:styled-content>2<\/jats:italic> expression level is highest in the lymphoid compartment of normal haematopoietic cells, specifically in T<\/jats:styled-content> cells. Analysis of TRIB<\/jats:styled-content>2<\/jats:italic> expression across 16 different subtypes of human leukaemia demonstrated that TRIB<\/jats:styled-content>2<\/jats:italic> expression was higher in ALL<\/jats:styled-content> phenotypes versus all other phenotypes including AML<\/jats:styled-content>, chronic lymphocytic leukaemia (CLL), myelodysplastic syndrome (MDS) and chronic myeloid leukaemia (CML). A T<\/jats:styled-content> cell profile was distinguished by high TRIB<\/jats:styled-content>2<\/jats:italic> expression in normal and malignant haematopoiesis. High TRIB<\/jats:styled-content>2<\/jats:italic> expression was seen in T<\/jats:styled-content>\u2010ALL<\/jats:styled-content> with normal karyotype and correlated with NOTCH<\/jats:styled-content> signalling pathways. High TRIB<\/jats:styled-content>2<\/jats:italic> expression correlated with NOTCH<\/jats:styled-content>1\/FBXW<\/jats:styled-content>7<\/jats:italic> mutations in a paediatric T<\/jats:styled-content>\u2010ALL<\/jats:styled-content> cohort, strongly linking NOTCH<\/jats:styled-content>1 activation and high TRIB<\/jats:styled-content>2<\/jats:italic> expression in paediatric T<\/jats:styled-content>\u2010ALL<\/jats:styled-content>. The relationship between TRIB<\/jats:styled-content>2<\/jats:italic> and T<\/jats:styled-content> cell signalling pathways uniquely identifies leukaemia subtypes and will be useful in the advancement of our understanding of T<\/jats:styled-content> cell and ALL<\/jats:styled-content> biology.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09222.x","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T12:34:16Z","timestamp":1341578056000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Elevated TRIB<\/scp>2<\/i> with NOTCH<\/scp>1<\/i> activation in paediatric\/adult T<\/scp>\u2010ALL<\/scp>"],"prefix":"10.1111","volume":"158","author":[{"given":"Maura M.","family":"Hannon","sequence":"first","affiliation":[{"name":"Department of Biochemsitry Biosciences Institute University College Cork Cork 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