{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:05:48Z","timestamp":1792058748962,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The main outcomes of the Programa Espa\u00f1ol para Tratamiento de Hemopat\u00edas (<jats:styled-content style=\"fixed-case\">PETHEMA<\/jats:styled-content>)\u2010acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>h\u201008 trial were described and compared with those of the historical <jats:styled-content style=\"fixed-case\">PETHEMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSTIBES<\/jats:styled-content>02 trial. The trials differed in imatinib dose (600 vs. 400\u00a0mg\/d) and amount of chemotherapy (one vs. two consolidation cycles) before stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>). All patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a029) enrolled in the <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>h\u201008 trial achieved complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) (vs. 90% in <jats:styled-content style=\"fixed-case\">CSTIBES<\/jats:styled-content>02), and <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> was performed in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> in 90% (vs. 78%). The reduction in early death, relapse before <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> and transplant\u2010related mortality observed in the <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>h\u201008 trial resulted in an improved 2\u2010year event\u2010free survival (63% vs. 37%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009).<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09240.x","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T11:53:13Z","timestamp":1343130793000},"page":"78-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Treatment of young patients with <scp>P<\/scp>hiladelphia chromosome\u2010positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"159","author":[{"given":"Josep\u2010Mar\u00eda","family":"Ribera","sequence":"first","affiliation":[{"name":"Department of Haematology ICO\u2010Hospital Germans Trias i Pujol Jose Carreras Leukaemia Research Institute Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Haematology ICO\u2010Hospital Germans Trias i Pujol Jose Carreras Leukaemia Research Institute Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Universitario y Polit\u00e9cnico La Fe Valencia 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