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The present study found that <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content> concentrations were higher in the supernatants of cultured bone marrow mononuclear cells from multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) patients than in healthy subjects. Serum <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content> levels were measured in samples from <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0209), monoclonal gammopathy of undetermined significance (<jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>) individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) and age\u2010matched controls\u00a0(<jats:italic>n<\/jats:italic>\u00a0=\u00a040). <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content> was detected in the serum of untreated <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a050) and levels were higher than in <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70157) and healthy subjects (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001). Serum <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content> levels were higher among patients with progressive disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a080) compared to those with responsive disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a079; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70038). Among all <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients, overall survival was shorter among patients whose serum <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content> levels were above the median (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001). We also demonstrated that sera from mice with human <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> xenografts contained human <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content>, and levels correlated with the change in tumour volume in response to melphalan or cyclophosphamide with bortezomib. These results suggest that serum <jats:styled-content style=\"fixed-case\">BCMA<\/jats:styled-content> levels may be a new biomarker for monitoring disease status and overall survival of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/j.1365-2141.2012.09241.x","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T06:44:29Z","timestamp":1342680269000},"page":"727-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":272,"title":["Serum <scp>B<\/scp>\u2010cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival"],"prefix":"10.1111","volume":"158","author":[{"given":"Eric","family":"Sanchez","sequence":"first","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kitto","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan T.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Yellin","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cydney M.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa P.","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameryn P.","family":"Ahles","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research West Hollywood CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Robinson","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Madden","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel N.","family":"Waterman","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina A.","family":"Swift","sequence":"additional","affiliation":[{"name":"James R. 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