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The anti\u2010cancer effectiveness of calcium salicylate has been investigated on human HT\u20101080 fibrosarcoma cell lines at relatively low concentrations (predominantly 0.4\u00a0m<jats:sc>m<\/jats:sc>) compared to those previously reported. Although low calcium salicylate concentrations did not retard tumour growth progression significantly, as measured by 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT) and time\u2010lapse assays, its cytotoxic characteristics were proven to be prominent by various morphological and immunocytological techniques. The results here demonstrate evidence for approximately 25% apoptosis after treatment with calcium salicylate, which up\u2010regulatd the expression of p53, p21 and Bax, and down\u2010regulated Bcl\u20102 in HT\u20101080 cells.<\/jats:p>","DOI":"10.1111\/j.1365-2184.2006.00390.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T23:29:50Z","timestamp":1152314990000},"page":"249-260","source":"Crossref","is-referenced-by-count":35,"title":["Calcium salicylate\u2010mediated apoptosis in human HT\u20101080 fibrosarcoma cells"],"prefix":"10.1111","volume":"39","author":[{"given":"J. G.","family":"Mahdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Alkarrawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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