{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:33:32Z","timestamp":1789421612989,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2003<\/jats:bold> To explore and compare the prevalence and expression of specific health\u2010related variables in a large survey sample of persons with agenesis of the corpus callosum (ACC) and their siblings.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Caregiver surveys of individuals with ACC (<jats:italic>n<\/jats:italic>\u2003=\u2003189) and their siblings (<jats:italic>n<\/jats:italic>\u2003=\u2003189) provided data regarding diagnoses, physical features, neurological and sensory information, feeding, elimination and sleep concerns, and some behavioural features.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Compared with their siblings, individuals with ACC had more concurrent conditions and were more likely to have altered pain perception and sensitivity to touch. In addition, individuals with ACC had more sensory deficits and abnormalities as well as altered patterns of feeding\/eating, elimination and sleep.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> These data raise important questions for future research and suggest the need for increased vigilance by caregivers and health\u2010care professionals of individuals with callosal disorders. Early detection and intervention may help prevent or ameliorate health problems in this population.<\/jats:p>","DOI":"10.1111\/j.1365-2214.2006.00602.x","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T14:08:22Z","timestamp":1143641302000},"page":"333-342","source":"Crossref","is-referenced-by-count":43,"title":["Health\u2010related issues in individuals with agenesis of the corpus callosum"],"prefix":"10.1111","volume":"32","author":[{"given":"D.","family":"Doherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Schilmoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schilmoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Badaruddin D.(2004)Social and behavioral problems of young children with agenesis of the corpus callosum.Unpublished Doctoral Dissertation.Fuller Theological Seminar Pasadena CA USA."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/135468000395781"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.09.008"},{"key":"e_1_2_6_5_1","first-page":"281","article-title":"Callosal agenesis and attention deficit hyperactivity disorder: a connection?","volume":"8","author":"Everett T.","year":"2002","journal-title":"Journal of the International Neuropsychological Society"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053898"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(87)80042-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140110107042"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001500609"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380401900609"},{"key":"e_1_2_6_11_1","unstructured":"Njiokiktjien C.(1991)Absence of the corpus callosum: Clincopathological correlations.In: Vol.3:The Child's Corpus Callosum(edsG.Ramaekers &C. Njiokiktjien) pp.235\u2013250.Suyi Publications Amsterdam the Netherlands."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0487-6_24"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-934X(03)00062-2"},{"key":"e_1_2_6_14_1","first-page":"224","article-title":"Filling a void: facilitating family support through networking for children with a rare disorder","volume":"13","author":"Schilmoeller G.","year":"2000","journal-title":"Family Science Review"},{"key":"e_1_2_6_15_1","volume-title":"The ACC Directory: Including Individuals with Agenesis of the Corpus Callosum and Related Conditions","author":"Schilmoeller K.","year":"1997"},{"key":"e_1_2_6_16_1","first-page":"5B","article-title":"Behavioral manifestations of elementary\u2010aged children with agenesis of the corpus callosum","volume":"62","author":"Sengenberger\u2010Rosenbery D.","year":"2001","journal-title":"Dissertation Abstracts International"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052407"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738020170122601"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/CBO9780511529320.004","volume-title":"Handbook of Early Childhood Intervention","author":"Shonkoff J. 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