{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:13:44Z","timestamp":1775636024161,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T00:00:00Z","timestamp":1091577600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Sensitization to house dust mite (HDM) is an important risk factor for the development of asthma and allergic disease in childhood. Higher levels of HDM allergen are linked to increased sensitization to HDM.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To study the effect of mite\u2010impermeable mattress encasings and an educational package on the development of allergies in a newborn cohort.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Six hundred and ninety\u2010six newborns at high risk of developing allergies were enrolled in three European countries (Germany, Austria, UK) in a prospective, randomized, controlled birth\u2010cohort study. Children were randomly assigned to an intervention and control group. Intervention measures included the use of mite\u2010impermeable mattress encasings for the child's bed and a simple educational package on allergen avoidance. The control group received basic information about allergies. Children were followed up at age 6, 12, 18 and 24 months.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> 80.9% of the children were followed up to the age of 24 months. No difference in the prevalence of sensitization to HDM (control vs. intervention group: 8.4% vs. 6.1%, <jats:italic>P<\/jats:italic>=0.33) or the development of symptoms (recurrent wheezing 10.3% vs. 10.7%, nocturnal cough 12.5% vs. 12.5%) or allergic diseases (asthma 3.5% vs. 5.1%, eczema 20.0% vs. 19.6%, rhinitis 28.9% vs. 25.8%) could be found between the control and intervention group.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> In this study, HDM avoidance did not show a protective effect on the development of sensitization to HDM or symptomatic allergy in children at age 24 months.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02024.x","type":"journal-article","created":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T14:31:29Z","timestamp":1091629889000},"page":"1220-1225","source":"Crossref","is-referenced-by-count":77,"title":["Effect of mite\u2010impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth\u2010cohort study \u2013 24 months results of the Study of Prevention of Allergy in Children in Europe"],"prefix":"10.1111","volume":"34","author":[{"given":"F.","family":"Horak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ihorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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