{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:30:08Z","timestamp":1789122608625,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Local corticosteroids are widely used in the treatment of nasal polyps and chronic rhinosinusitis both before and after nasal surgery. Their efficacy after functional endoscopic sinus surgery (FESS) has not been fully established by placebo\u2010controlled trials.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> This double\u2010blind placebo\u2010controlled randomized study was performed in order to investigate whether fluticasone propionate aqueous nasal spray (FPANS) reduces the recurrence rate of nasal polyps and chronic rhinosinusitis during the first year after FESS.<\/jats:p><jats:p><jats:bold>Patients and methods\n\t\t\t\t\t<\/jats:bold> The trial looked at 162 patients aged 18 years and older requiring FESS for chronic rhinosinusitis or nasal polyps. After FESS combined with peri\u2010operative systemic corticosteroids, patients were randomized and given FPANS 400\u2003\u03bcg b.i.d., FPANS 800\u2003\u03bcg b.i.d. or placebo b.i.d. for the duration of 1 year. Patients were withdrawn from the trial (but still included in the study for statistical purposes) if there were recurrent or persistent diseases, defined as progressive regrowth of nasal polyps, recurrent signs and symptoms of chronic sinusitis combined with abnormalities on computed tomography scan and persistent complaints for at least 2 months after FESS.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> A significant reduction of symptoms was seen after FESS. After 1 year, 46 patients had been withdrawn from the trial because of recurrent diseases and 32 patients because of persistent symptoms. No differences in the number of patients withdrawn because of recurrent or persistent diseases were found between the patients treated with FPANS and patients treated with placebo. We were also unable to find a positive effect of FPANS compared with placebo in several subgroups such as patients with nasal polyps, high score at FESS or no previous sinus surgery.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> This placebo\u2010controlled study does not show that treatment with FPANS up to 1 year after FESS had a positive effect compared with placebo.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02044.x","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T09:41:42Z","timestamp":1094204502000},"page":"1395-1400","source":"Crossref","is-referenced-by-count":75,"title":["Fluticasone propionate aqueous nasal spray does not influence the recurrence rate of chronic rhinosinusitis and nasal polyps 1 year after functional endoscopic sinus surgery"],"prefix":"10.1111","volume":"34","author":[{"given":"M. D.","family":"Dijkstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. A.","family":"Ebbens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M. L.","family":"Poublon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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