{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:59:31Z","timestamp":1792119571020,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T00:00:00Z","timestamp":1091577600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Ornamental <jats:italic>Ficus benjamina<\/jats:italic> (FB) has been recognized as a new indoor allergen. Little is known about the prevalence in moderately exposed subjects and the proposed association with fruit and <jats:italic>Hevea<\/jats:italic> latex hypersensitivity.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To study the prevalence of FB sensitization and the relationship with <jats:italic>Hevea<\/jats:italic> latex allergy, to identify cross\u2010reacting fruits, and to characterize the responsible allergens.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> A skin prick test solution prepared from FB latex (200\u2003\u03bcg\/mL) was included in our routine screening programme for suspect inhalant allergy. Patients reacting with the FB extract were further skin tested with exotic fruits by the prick\u2010to\u2010prick method. Inhibition of fig and FB CAP by FB latex, fig (<jats:italic>Ficus carica<\/jats:italic>), kiwi, the thiolproteases ficin and papain, <jats:italic>Hevea<\/jats:italic> latex and rHev b 6.02 (hevein) was performed in selected patients.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Of 2662 patients with a positive skin test to any aeroallergen, 66 (2.5%) reacted with FB. Ten patients showed isolated sensitization to FB. Although FB\u2010positive subjects were more often co\u2010sensitized to <jats:italic>Hevea<\/jats:italic> latex than FB\u2010negative (10.6% vs 3.8%, <jats:italic>P<\/jats:italic>&lt;0.01), nearly 90% tested negative for <jats:italic>Hevea<\/jats:italic> latex. Sensitization to FB was specifically associated with positive skin tests to fresh fig (83%), dried fig (37%), kiwi fruit (28%), papaya (22%), avocado (19%), banana (15%), and pineapple (10%) (<jats:italic>n<\/jats:italic>=54). Clinical reactions were reported mainly from fresh and dried fig and kiwi (47%, 60%, and 64%, respectively, of skin test\u2010positive patients), including seven patients with systemic reactions (urticaria, angiooedema, asthma). CAP to fig in 11 patients with clinical fruit allergy was inhibited on average by 87% by FB latex, 89% by fresh fig, 80% by dried fig, 38% by kiwi (100\u2003\u03bcg\/mL each), and by 59% and 44% by ficin and papain (50\u2003\u03bcg\/mL), respectively. No inhibition was obtained with <jats:italic>Hevea<\/jats:italic> latex and rHev b 6.02. CAP to FB was inhibited on average by 95% by FB, 60% by fresh fig, 41% by ficin, 29% by papain, and less than 7% by rubber latex allergens.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> Sensitization to FB latex is found in 2.5% of atopic individuals and mostly occurs independently of <jats:italic>Hevea<\/jats:italic> latex allergy. Sensitization is commonly associated with allergic reactions to figs and other tropical fruits (\u2018Ficus\u2010fruit syndrome\u2019). This cross\u2010reactivity is mediated at least in part by thiolproteases.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02046.x","type":"journal-article","created":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T14:31:29Z","timestamp":1091629889000},"page":"1251-1258","source":"Crossref","is-referenced-by-count":40,"title":["Sensitization to <i>Ficus benjamina<\/i>: relationship to natural rubber latex allergy and identification of foods implicated in the Ficus\u2010fruit syndrome"],"prefix":"10.1111","volume":"34","author":[{"given":"W.","family":"Hemmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Focke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jarisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"461","article-title":"Allergy to weeping fig","volume":"40","author":"Axelsson G","year":"1985","journal-title":"a new occupational disease"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1987.tb02193.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01033.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01149.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb00746.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050170001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01704.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056006584.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1987.tb00391.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01188.x"},{"key":"e_1_2_6_12_2","first-page":"24","article-title":"Asthma caused by Ficus benjamina latex","volume":"80","author":"Diez\u2010Gomez ML","year":"1998","journal-title":"evidence for cross-reactivity with fig fruit and papain"},{"key":"e_1_2_6_13_2","first-page":"588","article-title":"Feigenallergie. 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