{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:19:16Z","timestamp":1791328756911,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Caesarean\u2010section delivery has been associated with the subsequent development of atopy and wheezing in childhood.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To examine the association between mode of delivery (vaginal vs. caesarean section) and development of atopy, asthma and wheezing disorders in a population\u2010based cohort of children.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> The Avon Longitudinal Study of Parents and Children is a longitudinal birth cohort of children born 1 April 1991 to 31 December 1992. Mode of delivery was categorized as vaginal (including forceps and ventouse extractions) or caesarean section (elective and emergency). Primary outcomes were parental report of asthma or wheezing between 69 and 81 months of age, physician\u2010diagnosed asthma (PDA) at 91 months of age and atopy at 7 years by skin prick testing. Possible confounding factors were considered in a multivariable logistic regression model.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Total livebirths were 14\u2003062, from which were selected 12\u2003367 born to mothers resident in a defined area and delivered in one of two major obstetric hospitals. Of these infants, 10\u2003980 (88.8%) were delivered vaginally and 1387 (11.2%) by caesarean section. Outcome data were available for 7495 (61%) subjects (asthma 69\u201381 months); 7389 (60%) (wheeze 69\u201381 months); 7196 (58%) (PDA 91 months) and 5916 (48%) (atopy 7 years). Adjusted odds ratios [95%confidence interval] for caesarean section compared with vaginal delivery were not statistically significant for any outcome we considered: asthma 69\u201381 months 1.16 [0.9, 1.5]; wheeze 69\u201381 months 0.95 [0.7, 1.3]; PDA 1.14 [0.9, 1.4]; atopy 1.04 [0.8, 1.3].<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Delivery by caesarean section was not associated with the subsequent development of asthma, wheezing or atopy in later childhood in this population.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02048.x","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T05:41:42Z","timestamp":1094190102000},"page":"1349-1355","source":"Crossref","is-referenced-by-count":87,"title":["Mode of delivery is not associated with asthma or atopy in childhood"],"prefix":"10.1111","volume":"34","author":[{"given":"A.","family":"Maitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sherriff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Strachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ALSPAC Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,3]]},"reference":[{"issue":"5","key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2222.1998.028s5045.x","article-title":"The rising trends in asthma and allergic disease","volume":"28","author":"Von Mutius E.","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113048"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200207000-00004"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.34"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01667.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124046"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1610"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199905)27:5<318::AID-PPUL4>3.0.CO;2-E"},{"key":"e_1_2_7_11_2","first-page":"19","article-title":"Fecal microflora in healthy infants born by different methods of delivery","volume":"28","author":"Gr\u00f6nlund M\u2010M","year":"1999","journal-title":"permanent changes in intestinal flora after cesarean delivery"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00325.x"},{"key":"e_1_2_7_13_2","first-page":"F186","article-title":"Importance of intestinal colonisation in the maturation of humoral immunity in early infancy","volume":"83","author":"Gr\u00f6nlund M\u2010M","year":"2000","journal-title":"a prospective follow up study of healthy infants aged 0\u20136 months"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118130"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05104-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.4.262"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00006250-200103000-00023","article-title":"Mode of delivery and risk of respiratory diseases in newborns","volume":"97","author":"Levine EM","year":"2001","journal-title":"Obstet Gynecol"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2004.02048.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2004.02048.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T19:04:19Z","timestamp":1697223859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2004.02048.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1111\/j.1365-2222.2004.02048.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2004.02048.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}