{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:45:27Z","timestamp":1788403527443,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold>  <jats:italic>Artemisia vulgaris<\/jats:italic> is a widespread weed in the Mediterranean area and several allergens have been detected in its pollen. One of them, Art v 3, belongs to the lipid\u2010transfer protein (LTP) family and its prevalence in <jats:italic>Artemisia<\/jats:italic>\u2010sensitized patients or its relationship with other LTP allergens is not clear.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To assess the pattern of sensitization to an array of mugwort allergens in a Mediterranean population, and to study the cross\u2010reactivity of Art v 3 with Pru p 3 and Par j 1, relevant LTP allergens in the area.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Skin prick test was performed with whole extracts (<jats:italic>A. vulgaris, Parietaria judaica<\/jats:italic> and peach) and pure natural allergens Art v 1, Art v 3, Art v 60\u2003kDa and Par j 1 in 24 mugwort\u2010allergic patients from a Mediterranean area. <jats:italic>In vitro<\/jats:italic> assays included measurement of specific IgE and ELISA inhibition among LTP allergens.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The three <jats:italic>Artemisia<\/jats:italic> allergens elicited a positive skin response in 70\u201380% of the patients. Seven patients were clearly sensitized to Par j 1 and 11 to Pru p 3. There was no correlation between Par j 1 and Pru p 3 sensitization, but a highly significant correlation was found between peach extract and Art v 3 as regards the skin response. No IgE cross\u2010reactivity was observed between Art v 3\/Par j 1 or Pru p 3\/Par j 1. In contrast, Art v 3 significantly inhibited the binding to Pru p 3 of IgE from three patients' sera out of six studied, but Pru p 3 was not able to inhibit the IgE binding to Art v 3.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Art v 3 is a major mugwort allergen and in some patients with IgE to both Art v 3 and Pru p 3, Art v 3 behaves as the primary sensitizing agent.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02053.x","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T09:41:42Z","timestamp":1094204502000},"page":"1415-1421","source":"Crossref","is-referenced-by-count":118,"title":["Prevalence of sensitization to <i>Artemisia<\/i> allergens Art v 1, Art v 3 and Art v 60\u2003kDa. Cross\u2010reactivity among Art v 3 and other relevant lipid\u2010transfer protein allergens"],"prefix":"10.1111","volume":"34","author":[{"given":"M.","family":"Lombardero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"Garc\u00eda\u2010Sell\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jimeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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