{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:26:24Z","timestamp":1784607984631,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea\u2010pigs large\u2010diameter, neurofilament\u2010positive airway neurons.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> In the present study, the effect of NGF on tyrosine kinase receptor trkA and the capsaicin receptor TRPV1 expression in airway\u2010specific vagal sensory neurons located in the jugular\u2013nodose ganglia complex (JNC) of mice was investigated.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Using retrograde neuronal tracing in combination with double\u2010labelling immunohistochemistry, SP, trkA\u2010 and TRPV1\u2010receptor expression was examined in airway\u2010specific sensory neurons of BALB\/c mice before and after NGF treatment.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> NGF injected into the lower airway was able to induce SP (13.0\u00b12.03% vs. 5.9\u00b10.33%) and trkA expression (78\u00b12.66% vs. 60\u00b12.11%) in larger diameter (&gt;25\u2003\u03bcm), capsaicin\u2010insensitive and trkA\u2010positive vagal sensory neurons that were retrograde\u2010labelled with Fast Blue dye from the main stem bronchi.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Based on the extent of SP and trkA co\u2010expression in airway\u2010specific neurons by NGF treatment, the present study suggests that, following a peripheral activation of trkA receptor on SP afferent by NGF which is elevated in allergic inflammation, there may be trkA\u2010mediated SP induction to mediate neurogenic airway inflammation.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02066.x","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T09:41:42Z","timestamp":1094204502000},"page":"1474-1479","source":"Crossref","is-referenced-by-count":50,"title":["Nerve growth factor\u2010induced substance P in capsaicin\u2010insensitive vagal neurons innervating the lower mouse airway"],"prefix":"10.1111","volume":"34","author":[{"given":"Q. T.","family":"Dinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Groneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Peiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Springer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Joachim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Arck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. F.","family":"Klapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90777-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00210-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1094-5539(03)00049-X"},{"key":"e_1_2_6_5_2","first-page":"8","article-title":"Capsaicin\u2010sensitive and \u2010insensitive vagal bronchopulmonary C\u2010fibres in the mouse","volume":"8","author":"Kollarik M","year":"2003","journal-title":"J Physiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10081892"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00112.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07334.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(87)90113-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91293-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(85)90082-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217848"},{"key":"e_1_2_6_13_2","first-page":"816","article-title":"The capsaicin receptor","volume":"389","author":"Caterina MJ","year":"1997","journal-title":"a heat-activated ion channel in the pain pathway"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80564-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn0602-852"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.57.s72.3.x"},{"key":"e_1_2_6_17_2","first-page":"163","article-title":"Neurotrophins","volume":"118","author":"Braun A","year":"1999","journal-title":"a link between airway inflammation and airway smooth muscle contractility in asthma?"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3306916"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/337362a0"},{"key":"e_1_2_6_20_2","first-page":"143","article-title":"The neurotrophins and their receptors","volume":"18","author":"Maness LM","year":"1994","journal-title":"structure, function, and neuropathology"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119039"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00353.2001"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9908051"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90239-X"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/216173a0"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024053"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110153"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-002-0011-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00414.2001"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(01)00021-1"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4179(03)00065-9"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024054"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10955"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.6.9803023"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-21-08476.1997"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-05-01844.1999"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9808058"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00201-2"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.027656"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2004.02066.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2004.02066.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:04:29Z","timestamp":1697238269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2004.02066.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1111\/j.1365-2222.2004.02066.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2004.02066.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}