{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:27:59Z","timestamp":1791156479079,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Previous studies have shown a 10\u2010fold discrepancy of self\u2010reported food\u2010induced symptoms and physician\u2010diagnosed food hypersensitivity. Little information is available on the prevalence of food hypersensitivity in unselected paediatric populations. No data were available for German children.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To study the perception of food\u2010induced symptoms in the paediatric population, to investigate the allergens accused, to objectify patients' reports, and to identify subgroups at risk of having food\u2010induced allergy (FA) or non\u2010allergic food hypersensitivity (NAFH) reactions.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> This paper presents the data of the paediatric group (0\u201317 years) of a representative, randomly sampled, cross\u2010sectional population\u2010based survey studying 13\u2003300 inhabitants of the German capital city Berlin regarding food\u2010related symptoms. Instruments included mailed questionnaires, structured telephone interviews, physical examination, skin\u2010prick tests, specific serum IgE and standardized, controlled and blinded oral food challenges.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Two thousand three hundred and fifty\u2010four individuals were contacted by mailed questionnaire, 739 (31.4%) responses could be fully evaluated. Four hundred and fifty\u2010five (61.5%) participants reported symptoms related to food ingestion, 284 (38.4%) affirmed reproducible symptoms in the standardized telephone interview. One hundred and eighty\u2010four (24.8%) individuals were fully examined. Reproducible symptoms to food were found in 31 (4.2%) children and adolescents: 26 (3.5%) showed symptoms of FA and five (0.7%) of NAFH. The oral allergy syndrome was most often observed. Foods most commonly identified by oral challenges were apple, hazelnut, soy, kiwi, carrot and wheat.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The perception of food\u2010related symptoms is common among children and adolescents from the general population. Self\u2010reports could be confirmed in around one out of 10 individuals, still resulting in 4.2% of proven clinical symptoms. However, most reactions were mild and mainly because of pollen\u2010associated FA, while NAFH reactions were less common. Severe IgE\u2010mediated FA was observed in individuals with pre\u2010existing atopic disease, who should be fully investigated for clinically relevant FA.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02080.x","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T09:10:51Z","timestamp":1097572251000},"page":"1534-1541","source":"Crossref","is-referenced-by-count":206,"title":["Food allergy and non\u2010allergic food hypersensitivity in children and adolescents"],"prefix":"10.1111","volume":"34","author":[{"given":"C. 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