{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:34:53Z","timestamp":1778902493888,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T00:00:00Z","timestamp":1100217600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Given the morbidity and mortality of asthma and the recent dramatic increase in its prevalence, pharmacologic prophylaxis of this disease in children at risk would represent a major medical advance.<\/jats:p><jats:p><jats:bold>Objectives\n\t\t\t\t\t<\/jats:bold> The Preventia I Study was designed to evaluate the efficacy and long\u2010term safety of loratadine in reducing the number of respiratory infections in children at 24 months. A secondary objective was to investigate the benefit of loratadine treatment in preventing the onset of respiratory exacerbations.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Preventia I was a randomized placebo\u2010controlled study involving 22 countries worldwide. The children were 12\u201330 months of age at enrolment and had experienced at least five episodes of ENT infections, and no more than two episodes of wheezing during the previous 12 months. Phase I was a 12\u2010month double\u2010blind period during which the children were treated with loratadine 5\u2003mg\/day (2.5\u2003mg\/day for children24 months of age) or placebo. Phase II was a double\u2010blind follow\u2010up period without study medication.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Of the 412 children enrolled, 342 and 310 completed Phase I and Phase II, respectively. The results showed a significant decrease in the number of infections in the whole population of children. However, no difference was observed between the loratadine and placebo group. When considering secondary end\u2010points, loratadine was shown to reduce the number of respiratory exacerbations during the treatment phase. None of the 204 children who received loratadine discontinued the study because of drug\u2010related events. Loratadine treatment was not more sedative than placebo and was not associated with cardiovascular events.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> The strong decrease in the rate of infections in the children at risk of recurrent infections, while not being influenced by loratadine treatment, should encourage future reflection in terms of prophylactic management. This study also confirms the long\u2010term safety of loratadine and its metabolites in young children.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02098.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T19:19:36Z","timestamp":1100546376000},"page":"1665-1672","source":"Crossref","is-referenced-by-count":30,"title":["Prophylactic management of children at risk for recurrent upper respiratory infections: the Preventia I Study"],"prefix":"10.1111","volume":"34","author":[{"given":"A.","family":"Grimfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. T.","family":"Holgate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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