{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:46:19Z","timestamp":1787244379231,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T00:00:00Z","timestamp":1105574400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    The purpose was to evaluate serum concentrations of soluble intercellular adhesion molecule\u20101 (sICAM\u20101), CD14, IgE, IL\u20105 and IFN\u2010\u03b3 in children 6\u201310 years after an RSV infection and their correlation with subsequent asthma and atopy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    Fifty\u2010one subjects admitted to hospital for RSV infection during the first year of life and controls matched for birth date and sex underwent clinical examinations including lung function, skin prick and blood tests.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    The RSV subjects had significantly higher serum concentrations of IFN\u2010\u03b3 and sICAM\u20101 than the controls (for IFN\u2010\u03b3 224.9\u2003pg\/mL (standard deviation (SD) 271.3) vs. 187.1\u2003pg\/mL (372.9), difference 37.8\u2003pg\/mL, 95% confidence interval (CI) \u221290.3 to 166.0,\n                    <jats:italic>P<\/jats:italic>\n                    =0.05; for sICAM\u20101 170.2\u2003ng\/mL (SD 63) vs. 147.8\u2003ng\/mL (SD 57), difference 22.4\u2003ng\/mL, 95% CI \u22121.4 to 46.1,\n                    <jats:italic>P<\/jats:italic>\n                    =0.04). The RSV subjects with asthma had significantly higher concentrations of IFN\u2010\u03b3 than the controls with asthma, and the RSV subjects with wheezing during the previous 12 months had significantly higher concentrations of both IFN\u2010\u03b3 and sICAM\u20101 than the controls with wheezing.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    Children hospitalized for RSV infection in infancy still differ in IFN\u2010\u03b3 and sICAM\u20101 production 6\u201310 years after the infection. The data suggest that the pathomechanism of asthma and wheezing after an early RSV infection may be different from that of children without an early RSV infection.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.02125.x","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T05:54:47Z","timestamp":1105595687000},"page":"59-63","source":"Crossref","is-referenced-by-count":10,"title":["Serum concentrations of interferon\u2010\u03b3 and intercellular adhesion molecule\u20101 eight years after an early respiratory syncytial virus infection"],"prefix":"10.1111","volume":"35","author":[{"given":"H.","family":"Juntti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kokkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Dunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Renko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Karttunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Uhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0045-9380(93)90003-U"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.4.315"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9906076"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119516"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(200010)30:4<302::AID-PPUL5>3.0.CO;2-R"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/338473"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-11-2593"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9812025"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/340505"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70235-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(200008)30:2<131::AID-PPUL8>3.0.CO;2-S"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.16.3.9070618"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9902101"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214345"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.4049\/jimmunol.162.5.2997","article-title":"IL\u20105 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection","volume":"162","author":"Schwarze J","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1967851"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.4049\/jimmunol.156.12.4774","article-title":"Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells. 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