{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:12:08Z","timestamp":1792127528861,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> There are presently no placebo\u2010controlled data regarding the effects of butterbur (BB) on subjective and objective outcomes in patients with perennial allergic rhinitis.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We performed a placebo\u2010controlled evaluation of the effects of BB and fexofenadine (FEX) on subjective and objective outcomes in patients with perennial allergic rhinitis.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Sixteen patients with perennial allergic rhinitis and house dust mite sensitization were randomized in double\u2010blind cross\u2010over fashion to receive for 1 week either BB 50\u2003mg twice daily, FEX 180\u2003mg once daily and placebo (PL) once daily, or PL twice daily. The peak nasal inspiratory flow (PNIF) response to adenosine monophosphate (AMP) challenge administered as a single 400\u2003mg\/mL dose was measured over a 60\u2010min period after challenge, and domiciliary total nasal symptom score was recorded.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Pre\u2010challenge values for mean\u00b1SEM PNIF (L\/min) were not significantly different comparing all groups; BB (138\u00b18), FEX (140\u00b19), and PL (138\u00b18). The maximum % PNIF fall from baseline after nasal AMP challenge was significantly attenuated (<jats:italic>P<\/jats:italic>&lt;0.05) compared to PL (46\u00b13), with BB (34\u00b13) and FEX (39\u00b13). The area under the 60\u2010min time\u2013response curve (%.min) was also significantly attenuated (<jats:italic>P<\/jats:italic>&lt;0.05) compared to PL (1734\u00b1156), with BB (1052\u00b1258) and FEX (1194\u00b1161). There was also a significant reduction (<jats:italic>P<\/jats:italic>&lt;0.05) in total nasal symptom score with BB (1.8\u00b10.4) and FEX (1.8\u00b10.4), compared to PL (2.8\u00b10.5). There were no significant differences between BB and FEX for any outcomes.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> BB and FEX, in comparison to PL, were equally effective in attenuating the nasal response to AMP and in improving nasal symptoms, highlighting a potential role for BB in the treatment of allergic rhinitis.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.1903.x","type":"journal-article","created":{"date-parts":[[2004,4,9]],"date-time":"2004-04-09T14:13:58Z","timestamp":1081520038000},"page":"646-649","source":"Crossref","is-referenced-by-count":43,"title":["A placebo\u2010controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis"],"prefix":"10.1111","volume":"34","author":[{"given":"D. K. C.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fujihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Lipworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01158.x"},{"key":"e_1_2_6_3_2","first-page":"494","article-title":"Gastro\u2010protective effects by extracts of Petasites hybridus","volume":"59","author":"Brune K","year":"1993","journal-title":"the role of inhibition of peptido-leukotriene synthesis"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959492"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00552-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(02)00046-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7330.144"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.2003.01620.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.32"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1116OC"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01705.x"},{"key":"e_1_2_6_12_2","first-page":"16","article-title":"Peak inspiratory flow rate is more sensitive than acoustic rhinometry or rhinomanometry in detecting corticosteroid response with nasal histamine challenge","volume":"41","author":"Wilson AM","year":"2003","journal-title":"Rhinology"},{"key":"e_1_2_6_13_2","first-page":"317","article-title":"Adenosine provocation","volume":"165","author":"Holgate ST.","year":"2002","journal-title":"a new test for allergic type airway inflammation"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01776.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62712-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70256-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053725"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.4083"},{"issue":"73","key":"e_1_2_6_19_2","first-page":"146","article-title":"Influence of fexofenadine on tumour necrosis factor alpha stimulated H292 epithelial cell activation in vitro","volume":"57","author":"Hoda U","year":"2002","journal-title":"Allergy"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2004.1903.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2004.1903.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:04:02Z","timestamp":1697439842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2004.1903.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,3]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1365-2222.2004.1903.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2004.1903.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,3]]}}}