{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:33:14Z","timestamp":1700544794802},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,4,9]],"date-time":"2004-04-09T00:00:00Z","timestamp":1081468800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Allergens are common non\u2010infectious antigens to which people will mount T cell dependent humoral responses. Among genetically susceptible individuals, an antigen\u2010specific response results involving the production of allergen\u2010specific IgE (atopy).<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> Determine if this susceptibility is manifested as an inherited, allergen\u2010specific trait or a random response to allergens among susceptible people.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> We evaluated allergen\u2010specific outcomes in 1099 members of families with positive atopic history (26 multi\u2010generation and 112 nuclear families). Each was tested for sensitivity to 14 common allergens by standardized skin prick test (SPT), a marker of specific IgE production. Over 15\u2003000 individual SPT's were evaluated. Among five randomly selected multi\u2010generation families (<jats:italic>N<\/jats:italic>=163), semi\u2010quantitative determinations of Amb a 1\u2010specific IgA1,2 and IgG1\u20134 were determined in three groups: (A) Amb a SPT<jats:sup>+<\/jats:sup>\/Amb a 1\u2010IgE<jats:sup>+<\/jats:sup>, (B) Amb a SPT<jats:sup>\u2212<\/jats:sup>\/Amb a 1\u2010IgE<jats:sup>+<\/jats:sup>, (C) Amb a SPT<jats:sup>\u2212<\/jats:sup>\/Amb a 1\u2010IgE<jats:sup>\u2212<\/jats:sup>.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> By rank correlation statistics, there were no discernible \u2018patterns\u2019 of specific SPT outcomes among any of the multi\u2010generation families, suggesting that environmental exposure rather than allergen\u2010specific inheritance determined the responses. This was confirmed among the nuclear families since the conditional SPT outcomes among children were independent of the SPT responses of their parents. Among five randomly selected multi\u2010generation families, the relative proportionate concentrations of the Amb a 1\u2010specific IgA and IgG subclasses were comparable, regardless of atopic sensitization to the ragweed allergen Amb a.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> While the general propensity for atopy may be inherited, an individual's specific atopic outcome is a random variable independent of familial sensitization patterns.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.1920.x","type":"journal-article","created":{"date-parts":[[2004,4,9]],"date-time":"2004-04-09T14:13:58Z","timestamp":1081520038000},"page":"540-547","source":"Crossref","is-referenced-by-count":8,"title":["Random outcomes of allergen\u2010specific responses in atopic families"],"prefix":"10.1111","volume":"34","author":[{"given":"D. R.","family":"Jackola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Liebeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00108-6"},{"key":"e_1_2_6_3_2","first-page":"587","article-title":"Expression of IgH chain genes in antibody response to ragweed and purified Amb a 1","volume":"36","author":"Allauzen S","year":"1999","journal-title":"evidence for differential regulation of isotype production"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236390"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236537"},{"key":"e_1_2_6_6_2","volume-title":"Genetics of Allergy and Asthma","author":"Blumenthal MN","year":"1997"},{"key":"e_1_2_6_7_2","first-page":"20","volume-title":"Genetic and Environmental Factors In Clinical Allergy","author":"Marsh DG.","year":"1990"},{"key":"e_1_2_6_8_2","first-page":"39","volume-title":"Allergens and Allergen Immunotherapy","author":"Blumenthal MN","year":"1999"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(96)80110-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.829"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(01)00298-9"},{"key":"e_1_2_6_12_2","first-page":"21","article-title":"Genetics and molecular genetics of the MHC","volume":"1","author":"Rhodes DA","year":"1999","journal-title":"Rev Immunogenetics"},{"key":"e_1_2_6_13_2","volume-title":"Genetics of Asthma and Atopy","author":"Moffat MF"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_6_15_2","first-page":"873","article-title":"Atopic disease and immunoglobulin E in twins reared apart and together","volume":"48","author":"Hanson B","year":"1991","journal-title":"Am J Human Genet"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70099-F"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00321.x"},{"key":"e_1_2_6_18_2","first-page":"198","article-title":"Approaches toward the genetic analysis of complex traits","volume":"54","author":"Marsh DG.","year":"1999","journal-title":"asthma and atopy"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s004310051024","article-title":"Risk factors for allergy","volume":"158","author":"De Swert LFA.","year":"1999","journal-title":"Eur J Pediatr"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0497-389"},{"key":"e_1_2_6_21_2","first-page":"1285","article-title":"Standardization of spirometry \u2013 1987 update","volume":"153","author":"American Thoracic Society.","year":"1987","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_6_22_2","first-page":"308","volume-title":"Introduction to Statistical Inference","author":"Keeping ES.","year":"1995"},{"key":"e_1_2_6_23_2","first-page":"114","volume-title":"An Introduction To probability Theory and its Applications","author":"Feller W.","year":"1968"},{"key":"e_1_2_6_24_2","first-page":"106","article-title":"Distribution of IgE in a community population sample","volume":"68","author":"Barbee RA","year":"1981","journal-title":"correlations with age, sex, and allergen skin test reactivity"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/366421a0"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00910.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.supplement_2.ras-14"},{"key":"e_1_2_6_28_2","first-page":"197","volume-title":"Genetics of Allergy and Asthma","author":"Marsh DG","year":"1997"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.9.3588"},{"key":"e_1_2_6_30_2","doi-asserted-by":"crossref","unstructured":"JackolaDR Pierson\u2010MullanyL BlumenthalMN RosenbergA. Allergen skin test reaction patterns in children (10 y.o.) from atopic families suggest age\u2013dependent changes in allergen\u2010IgE binding in early life. Int Arch Allergy Immunol2003;132:364\u201372.","DOI":"10.1159\/000074904"},{"key":"e_1_2_6_31_2","first-page":"240","article-title":"The art of the probable","volume":"293","author":"Germain RN.","year":"2001","journal-title":"system control in the adaptive immune system"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.005015"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2004.1920.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2004.1920.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:02:26Z","timestamp":1697439746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2004.1920.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1365-2222.2004.1920.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2004.1920.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}