{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:54:18Z","timestamp":1790243658374,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,4,9]],"date-time":"2004-04-09T00:00:00Z","timestamp":1081468800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Atopy in maternal and family histories is known to be a risk factor for elevated umbilical cord immunoglobulin E (cIgE). However, the association between cIgE and psychosocial factors remains under investigation.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To explore whether psychosocial factors in addition to atopy contribute to elevated cIgE.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Four private maternity hospitals fitting the quantile levels of SO<jats:sub>2<\/jats:sub> in 2000 cooperated with us by recruiting participants for this study: pairs of mothers and neonates living within 3\u2010km catchment areas of air\u2010monitoring stations. We used a questionnaire to collect exposure data, and the Pharmacia UniCap IgE assay test system to determine the levels of IgE in gravidas and cord blood.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Between July 2001 and March 2003, 334 mother and neonate pairs participated in this study. The frequencies of sensitization, serum IgE (sIgE)&gt;100\u2003IU\/mL, or cIgE0.35\u2003IU\/mL were not different between the four different hospitals. By multi\u2010variate logistic regression analysis adjusted for environmental factors, genetic factors, and psychosocial factors, the risk factors for elevated cIgE were being a male neonate (odds ratio (OR)=3.5, 95% confidence interval (CI)=[1.5, 8.5]), carpets at home (OR=3.0, 95% CI=[1.02, 8.4]), maternal allergy to dog dander (OR=9.7, 95% CI=[1.2, 98.8], maternal total serum IgE&gt;100\u2003IU\/mL (OR=5.1, 95% CI=[2.2, 12.8]), maternal regularly\/mostly\/often self\u2010reported nervousness (OR=4.0, 95% CI=[1.3, 12.8]), family income $11\u2003574\u201317\u2003361\/year (OR=3.7, 95% CI=[1.3, 11.5]), incense burning (OR=4.0, 95% CI=[1.4, 13.3]), and atopy in maternal grandparents (OR=4.8, 95% CI=[1.7, 14.0]). By principle component analysis and logistic regression, psychosocial stress (\u03b2\u00b1standard error=0.26\u00b10.13, <jats:italic>P<\/jats:italic>=0.04) was associated with increased cIgE.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Psychosocial factors are potentially important risk factors for elevated cIgE.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.1928.x","type":"journal-article","created":{"date-parts":[[2004,4,9]],"date-time":"2004-04-09T14:13:58Z","timestamp":1081520038000},"page":"548-554","source":"Crossref","is-referenced-by-count":59,"title":["Are maternal psychosocial factors associated with cord immunoglobulin E in addition to family atopic history and mother immunoglobulin E?"],"prefix":"10.1111","volume":"34","author":[{"given":"Y.\u2010C.","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010J.","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010L.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. L.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00117.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s3439"},{"key":"e_1_2_6_4_2","first-page":"392","article-title":"Genetic and environmental influences on atopic immune response in early life","volume":"9","author":"Lopez N","year":"1999","journal-title":"J Invest Allerg Clin Immunol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.2.347"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.991071001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.459"},{"key":"e_1_2_6_8_2","first-page":"149","article-title":"Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention","volume":"11","author":"Halken S","year":"2000","journal-title":"a prospective, randomized study"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00168-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(03)00025-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23719.x"},{"key":"e_1_2_6_12_2","first-page":"296","article-title":"High prevalence of asthma in preschool children in Southern Brazil","volume":"35","author":"Chatkin MN","year":"2003","journal-title":"a population-based study"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00594.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007361013917"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb02484.x"},{"key":"e_1_2_6_16_2","first-page":"443","article-title":"Influence of maternal smoking on cord serum IgE levels in newborns","volume":"45","author":"Flores D'Arcais A","year":"1993","journal-title":"Minerva Pediatr"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00488.x"},{"key":"e_1_2_6_18_2","first-page":"587","article-title":"The prevalence of and risk factors for atopy in early childhood","volume":"101","author":"Tariq SM","year":"1998","journal-title":"a whole population birth cohort study"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1994.tb00223.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80009-7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01543.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00118.x"},{"key":"e_1_2_6_23_2","first-page":"419","article-title":"Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States","volume":"110","author":"Leaderer BP","year":"2002","journal-title":"impact of socioeconomic factors and population density"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.6.2011107"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/nur.1027"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0668.2003.00197.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(03)00124-3"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0048-9697(99)00276-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010164"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00036-0"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00111.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2003.00466.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.120273"},{"issue":"15","key":"e_1_2_6_34_2","first-page":"55","article-title":"The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study","volume":"13","author":"Brunekreef B","year":"2002","journal-title":"design and first results"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.6.478"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(02)00194-X"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2004.1928.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2004.1928.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:02:56Z","timestamp":1697439776000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2004.1928.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1365-2222.2004.1928.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2004.1928.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}