{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:18:17Z","timestamp":1790756297717,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T00:00:00Z","timestamp":1084320000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The nature of the association between severe respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing remains unknown. In a previous study, we showed that genetic variation in the IL\u20108\u2010promoter region is associated with susceptibility to severe bronchiolitis.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The purpose of this study was to assess the association between wheezing post\u2010bronchiolitis and the genetic variant of IL\u20108 gene.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> We collected data from 134 children who had suffered from bronchiolitis, enrolled in our previous study. The occurrence of wheezing post\u2010bronchiolitis was recorded from a questionnaire sent by post. The association between the genotype and wheezing phenotype was assessed by family\u2010based and case\u2013control approaches.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Family\u2010based association showed that the IL\u20108 variant was transmitted significantly more often than expected in the children who wheezed after the episode of bronchiolitis (transmission=56%, <jats:italic>P<\/jats:italic>=0.02). This effect was not observed in the group of children who had bronchiolitis but did not go on to wheeze. Moreover, the variant was significantly more frequent in post\u2010bronchiolitis wheezers compared with the general population (odds ratio=1.6, 95% confidence interval 1.0\u20132.6).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> These preliminary results suggest that there is a genetic predisposition to wheeze following severe RSV bronchiolitis.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2004.1947.x","type":"journal-article","created":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T15:26:32Z","timestamp":1084375592000},"page":"801-803","source":"Crossref","is-referenced-by-count":49,"title":["Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis"],"prefix":"10.1111","volume":"34","author":[{"given":"T.","family":"Goetghebuer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Isles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.supplement_1.maic-11"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.5.428"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.12.1023"},{"key":"e_1_2_6_7_2","first-page":"81","article-title":"Prevalence of wheeze during childhood","volume":"16","author":"Kuehni CE","year":"2000","journal-title":"retrospective and prospective assessment"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04958-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/302577"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.791"},{"key":"e_1_2_6_11_2","first-page":"2367","article-title":"Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis","volume":"29","author":"Amoli MM","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_2","first-page":"506","article-title":"Genetic susceptibility to enteroaggregative Escherichia coli diarrhea","volume":"188","author":"Jiang ZD","year":"2003","journal-title":"polymorphism in the interleukin-8 promoter region"},{"key":"e_1_2_6_13_2","first-page":"3560","article-title":"Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator\u2010activated receptor gamma with colorectal cancer","volume":"63","author":"Landi S","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/376559"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1038-x"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2004.1947.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2004.1947.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:54:57Z","timestamp":1697406897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2004.1947.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1365-2222.2004.1947.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2004.1947.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}