{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:15:36Z","timestamp":1777500936525,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T00:00:00Z","timestamp":1105574400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> We have previously reported an association between low IgA and allergic manifestations in early childhood (0\u20132 years) and have now followed our cohort for an additional 2 years.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To evaluate in a longitudinal community\u2010based cohort study the association between maturation of Ig production and allergic manifestations in the first 4 years of life.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> A cohort of 161 randomly selected children was followed from birth to the age of 42\u201348 months and evaluated at 18\u201323 months (EV1; <jats:italic>n<\/jats:italic>=179) and again at the age of 42\u201348 months (EV2; <jats:italic>n<\/jats:italic>=161). Diagnoses were made with the help of a clinical questionnaire, physical examination and skin prick tests (SPTs) to 10 common allergens. Serum immunoglobulins were measured at EV1 and EV2, and salivary IgA (sal\u2010IgA) at EV2.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Serum IgA, IgE, IgG1, IgG2 and IgG4 increased from 2 to 4 years of age (<jats:italic>P<\/jats:italic>&lt;0.001) and their levels showed close correlations (<jats:italic>P<\/jats:italic>0.01 for most comparisons). Children with one or more positive SPTs had lower serum IgA (<jats:italic>P<\/jats:italic>=0.004) and IgG4 (<jats:italic>P<\/jats:italic>=0.05) at EV2 than those who did not respond, and children who developed allergic rhinitis between EV1 and EV2 had low sal\u2010IgA (<jats:italic>P<\/jats:italic>=0.006) and IgG3 (<jats:italic>P<\/jats:italic>&lt;0.05) at EV2. Atopic eczema was associated with low sal\u2010IgA at EV2, and children who developed eczema between EV1 and EV2 had significantly lower sal\u2010IgA than those who recovered after EV1 (<jats:italic>P<\/jats:italic>=0.02).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Allergic manifestations in predisposed children may be influenced by the rate of maturation of immunological components that counteract sensitization or inhibit effector mechanisms of allergy.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02141.x","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T10:54:47Z","timestamp":1105613687000},"page":"64-69","source":"Crossref","is-referenced-by-count":28,"title":["Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre\u2010school children: a follow\u2010up community\u2010based study"],"prefix":"10.1111","volume":"35","author":[{"given":"B. 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