{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:42:00Z","timestamp":1782513720570,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T00:00:00Z","timestamp":1105574400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> We recently found that paracetamol (acetaminophen) use in late pregnancy was associated with an increased risk of early wheezing in the offspring.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To see whether use of paracetamol in late pregnancy is associated with an increased risk of asthma, wheezing and other atopic outcomes in the child at school age.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> In the population\u2010based Avon Longitudinal Study of Parents and Children, we measured associations of paracetamol and aspirin use in late pregnancy (20\u201332 weeks) with asthma, hayfever, eczema (<jats:italic>n<\/jats:italic>=8511) and wheezing (8381) in the offspring at 69\u201381 months, and with atopy (positive skin prick test to <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>, cat or grass, <jats:italic>n<\/jats:italic>=6527) and blood total IgE (<jats:italic>n<\/jats:italic>=5148) at 7 years. We used logistic and linear regression to analyse binary outcomes and log\u2010transformed IgE, respectively, controlling for potential confounders.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Use of paracetamol, but not aspirin, in late pregnancy was positively associated with asthma (odds ratios (ORs), comparing children whose mothers took paracetamol \u2018sometimes\u2019 and \u2018most days\/daily\u2019 with those whose mothers never took it, 1.22 (95% confidence interval (CI): 1.06\u20131.41) and 1.62 (95% CI: 0.86\u20133.04), respectively; <jats:italic>P<\/jats:italic> trend=0.0037), wheezing (ORs 1.20 (95% CI: 1.02\u20131.40) and 1.86 (95% CI: 0.98\u20133.55), respectively; <jats:italic>P<\/jats:italic> trend=0.011), and total IgE (geometric mean ratios 1.14 (95% CI: 1.03\u20131.26) and 1.52 (95% CI: 0.98\u20132.38), respectively; <jats:italic>P<\/jats:italic> trend=0.0034), but not hayfever, eczema or skin test positivity. The proportion of asthma attributable to paracetamol use in late pregnancy, assuming a causal relation, was 7%.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Paracetamol exposure in late gestation may cause asthma, wheezing and elevated IgE in children of school age.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02151.x","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T10:54:47Z","timestamp":1105613687000},"page":"18-25","source":"Crossref","is-referenced-by-count":166,"title":["Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood"],"prefix":"10.1111","volume":"35","author":[{"given":"S. O.","family":"Shaheen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Newson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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