{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:49:56Z","timestamp":1791269396329,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,21]],"date-time":"2005-02-21T00:00:00Z","timestamp":1108944000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Farmers' children are less frequently sensitized to common allergens than the non\u2010farmers' children, but less is known about their sensitization to other allergens and its association with clinical diseases.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To examine the association of farm environment with atopic sensitization, allergic diseases, expression of allergen\u2010induced symptoms, and the importance of specific sensitization against \u2018common\u2019 (timothy, dog, cat, birch, <jats:italic>Dermatophagoides pteronyssimus<\/jats:italic>, mugwort) and \u2018other\u2019 (cockroach, horse, <jats:italic>Lepidoglyphus destructor<\/jats:italic>, cow) allergens for asthma and allergic diseases in children.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> A cross\u2010sectional study including 344 farmers' and 366 non\u2010farmers' children aged 6\u201313 years in eastern Finland, using a self\u2010administered written questionnaire and skin prick tests against the above\u2010mentioned allergens.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Farmers' children had less asthma and allergic diseases and were less often sensitized against common allergens than the non\u2010farmers' children. However, little difference was observed in sensitization against the other allergens between the farmers' (17.2%) and non\u2010farmers (14.5%) children [adjusted odds ratios (aOR) 1.11 (0.71\u20131.72)]. Being sensitized against only other allergens, without sensitization against common allergens, was unrelated to asthma or allergic diseases. Among the single allergens, sensitization against pets or pollen, or against horse or cow, had the strongest association with asthma, hayfever, and atopic eczema; no such association was seen in <jats:italic>D. pteronyssimus<\/jats:italic>, mugwort, cockroach, or <jats:italic>L. destructor<\/jats:italic>. Farmers' children had significantly less often symptoms of allergic rhinitis in contact with dog (aOR 0.32%, 95% confidence interval (CI) 0.15\u20130.67), cat (aOR 0.45, 0.22\u20130.88), or pollen (aOR 0.58%, 95% CI 0.37\u20130.90) than the non\u2010farmers' children.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Farm environment reduces the occurrence of asthma, allergic diseases, and atopic sensitization in children, and also the occurrence of allergen\u2010induced rhinitis. Remarkable differences were observed between single allergens in their association with allergic disease, stressing the importance of allergen selection when defining atopy in epidemiological studies.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02172.x","type":"journal-article","created":{"date-parts":[[2005,2,21]],"date-time":"2005-02-21T16:36:45Z","timestamp":1109003805000},"page":"160-166","source":"Crossref","is-referenced-by-count":37,"title":["Allergen\u2010specific sensitization in asthma and allergic diseases in children: the study on farmers' and non\u2010farmers' children"],"prefix":"10.1111","volume":"35","author":[{"given":"S. T.","family":"Remes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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