{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:01:33Z","timestamp":1790406093147,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,4,11]],"date-time":"2005-04-11T00:00:00Z","timestamp":1113177600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The dysfunction of the mucosal interface of the upper respiratory tract in cystic fibrosis (CF) patients is clinically visible by the development of nasal polyps (NP) at a young age. Innate defence markers and inflammatory mediators in NP from patients with CF were compared with non\u2010cystic fibrosis nasal polyps (non\u2010CF\u2010NP) to determine a possible different immunological background in macroscopically similar tissue.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Surgical samples were obtained from patients with non\u2010CF\u2010NP, cystic fibrosis patients with nasal polyps (CF\u2010NP) and control patients (CO). With real time PCR, the mRNA expression of human \u03b2 defensins (HBD) 2 and 3, toll\u2010like receptors (TLR) 2 and 4 and the macrophage mannose receptor (MMR) were measured. On homogenates of the surgical samples eotaxin, myeloperoxidase (MPO), IL\u20105 and IL\u20108 protein content was measured using commercial ELISA kits; IgE and eosinophilic cationic protein (ECP) were measured by the Unicap system.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> In CF\u2010NP we found a statistically significant higher mRNA expression of HBD 2 compared with non\u2010CF\u2010NP and CO and of TLR 2 compared with non\u2010CF\u2010NP. In the non\u2010CF\u2010NP group, MMR mRNA expression was significantly elevated compared with CO and CF\u2010NP. For TLR 4 mRNA expression no statistically significant differences were found between groups. IL\u20105 was below detection level in all CO and CF\u2010NP, but was measurable in 80% of the non\u2010CF\u2010NP. MPO and IL\u20108 concentrations were significantly higher in CF\u2010NP compared with CO and non\u2010CF\u2010NP, whereas ECP, eotaxin and IgE were significantly higher in the non\u2010CF\u2010NP group.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> We here demonstrate that CF\u2010NP and non\u2010CF\u2010NP not only differ in terms of inflammatory mediator profile, but also in terms of innate markers.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02215.x","type":"journal-article","created":{"date-parts":[[2005,4,11]],"date-time":"2005-04-11T19:38:59Z","timestamp":1113248339000},"page":"467-472","source":"Crossref","is-referenced-by-count":64,"title":["Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators"],"prefix":"10.1111","volume":"35","author":[{"given":"S.","family":"Claeys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Van 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