{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:39:39Z","timestamp":1759333179450},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The significance of specific T cell receptor (TCR) V\u03b2 subtypes and human leucocyte antigen (HLA) class II alleles for the development of allergy to lipocalin allergens such as the major dog allergen Can f 1 is not clear at present.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To characterize the TCR V\u03b2 usage in the Can f 1\u2010specific T cell lines and the HLA class II genotypes of Can f 1\u2010allergic and non\u2010allergic subjects.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> T cell lines were induced with recombinant Can f 1 from the peripheral blood mononuclear cells of 12 non\u2010atopic dog owners and 26 dog\u2010allergic patients. Thirteen of the dog\u2010allergic subjects were sensitized to Can f 1. Expression of the TCR V\u03b2 subtypes on CD4<jats:sup>+<\/jats:sup> T cells in the T cell lines was measured by flow cytometry. The subjects were HLA genotyped for DRB1, DQB1 and DPB1 loci.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Can f 1\u2010specific T cell lines were obtained from 18 subjects, with either positive (<jats:italic>n<\/jats:italic>=8) or negative (<jats:italic>n<\/jats:italic>=10) skin prick tests (SPTs) to recombinant Can f 1. The frequency of TCR V\u03b25.1<jats:sup>+<\/jats:sup> T cells was significantly higher in the T cell lines of subjects with negative SPTs to the allergen. Moreover, DR4\u2013DQ8 haplotype was over\u2010represented among these subjects.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> The DR4\u2013DQ8 haplotype and the TCR V\u03b25.1<jats:sup>+<\/jats:sup> CD4<jats:sup>+<\/jats:sup> T cells may be protective against allergy to Can f 1.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02247.x","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:41:13Z","timestamp":1119375673000},"page":"797-803","source":"Crossref","is-referenced-by-count":16,"title":["The DR4\u2013DQ8 haplotype and a specific T cell receptor V\u03b2 T cell subset are associated with absence of allergy to Can f 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