{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:00Z","timestamp":1791274380824,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:00:00Z","timestamp":1119312000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To evaluate the influence of perinatal environmental factors on early sensitization, atopic dermatitis and wheezing during the first year.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Information on pregnancy\u2010related factors, parental atopic history, environmental factors and the clinical course of the infant until age one was gathered by questionnaires, as part of a prospective birth cohort study (Prospective study on the Influence of Perinatal factors on the Occurrence of asthma and allergies [PIPO\u2010study]). Quantification of total and specific IgE was performed in 810 children and their parents.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Early sensitization was found in 107\/810 (13%) of the infants. Multiple regression analysis showed that specific IgE in fathers was a risk factor for early sensitization in their daughters (adjusted odds ratios (OR<jats:sub>adj<\/jats:sub>) 2.21 (95% confidence interval (CI) 1.10\u20134.49); <jats:italic>P<\/jats:italic>=0.03), whereas in boys, day care attendance was shown to be protective for early sensitization (OR<jats:sub>adj<\/jats:sub> 0.38 (95% CI 0.20\u20130.71); <jats:italic>P<\/jats:italic>=0.001). Atopic dermatitis occurred in 195\/792 infants (25%). Specific IgE in the mother (OR<jats:sub>adj<\/jats:sub> 1.52 (95% CI 1.06\u20132.19); <jats:italic>P<\/jats:italic>=0.02) and in the infant (OR<jats:sub>adj<\/jats:sub> 4.20 (95% CI 2.63\u20136.68); <jats:italic>P<\/jats:italic>&lt;0.001) were both risk factors for the occurence of atopic dermatitis, whereas postnatal exposure to cats was negatively associated with atopic dermatitis (OR<jats:sub>adj<\/jats:sub> 0.68 (0.47\u20130.97); <jats:italic>P<\/jats:italic>=0.03).<\/jats:p><jats:p>Postnatal exposure to cigarette smoke (OR<jats:sub>adj<\/jats:sub> 3.31 (95% CI 1.79\u20136.09); <jats:italic>P<\/jats:italic>&lt;0.001) and day care attendance (OR<jats:sub>adj<\/jats:sub> 1.96 (95% CI 1.18\u20133.23); <jats:italic>P<\/jats:italic>=0.009) were significantly associated with early wheezing, which occurred in 25% (197\/795) of the infants.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> The effect of paternal sensitization and day care attendance on sensitization is gender dependent. Maternal sensitization predisposes for atopic dermatitis, whereas postnatal exposure to cats had a protective effect.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02254.x","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:41:13Z","timestamp":1119375673000},"page":"733-740","source":"Crossref","is-referenced-by-count":48,"title":["Perinatal risk factors for sensitization, atopic dermatitis and wheezing during the first year of life (PIPO study)"],"prefix":"10.1111","volume":"35","author":[{"given":"M. M.","family":"Hagendorens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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