{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:22:59Z","timestamp":1772806979876,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T00:00:00Z","timestamp":1133481600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Asthma is accepted as a disease characterized by airway inflammation, with evidence that airway structural changes, or \u2018remodelling\u2019 occurs. There are few studies relating airway physiology, inflammation and remodelling, however. We have carried out a study of inter\u2010relationships between airway inflammation, airway remodelling, reticular basement membrane (RBM) thickening, and bronchial hyper\u2010reactivity (BHR), before and after high\u2010dose inhaled corticosteroid (fluticasone propionate 750\u2003\u03bcg\u2003b.d.), in a group of relatively mild but symptomatic, steroid na\u00efve asthma patients.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Double\u2010blind, randomized, placebo\u2010controlled, parallel group study of inhaled corticosteroid (ICS) in 35 asthmatics, with bronchoalveolar lavage (BAL) and airway endobronchial biopsy (EBB) for inflammatory cell profiles and EBB for airway remodelling carried out at baseline, 3 and 12 months.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> At baseline RBM thickening was related to BAL mast cells and EBB eosinophil counts. In turn baseline log EBB EG2 eosinophil count, log%BAL epithelial cells and log\u2003RBM thickness explained 55% of the variability in BHR.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> We provide new information that airway inflammation, remodelling, and BHR in asthma are inter\u2010related and improved by ICS therapy. Our data potentially support the need for early and long\u2010term intervention with ICS even in relatively mild asthmatics, and the need to further assess the potential merit of longitudinal BHR testing in management of some patients, as this may reflect both airway inflammation and remodelling.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2005.02365.x","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T14:20:45Z","timestamp":1143642045000},"page":"1565-1571","source":"Crossref","is-referenced-by-count":42,"title":["Inter\u2010relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper\u2010reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"C.","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E.","family":"Orsida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Feltis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Johns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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