{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:26:01Z","timestamp":1791174361459,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Allergic rhinoconjunctivitis is a common complex disorder characterized by itching and irritation in the nose, bouts of sneezing, watery rhinorrhoea, nasal congestion and itchy eyes with tears and swelling. Like other atopic disorders such as allergic asthma and atopic dermatitis, the development involves complex interactions of genes and environmental factors.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The purpose of this study was to identify susceptibility loci for allergic rhinoconjunctivitis.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> We conducted a genome\u2010wide linkage analysis using a non\u2010parametric, affected\u2010relative\u2010pair method. The 250 families used were collected originally for an atopic dermatitis linkage study.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Three regions showed favour in evidence of linkage to allergic rhinoconjunctivitis: 3q13 (D3S1278: logarithm of odds ratio (LOD)=1.64, <jats:italic>P<\/jats:italic>&lt;0.003), 4q34\u201335 (D4S1652: LOD=1.49, <jats:italic>P<\/jats:italic>&lt;0.005) and 18q12 (D18S535: LOD=1.94, <jats:italic>P<\/jats:italic>&lt;0.002). In addition, four regions showed weaker evidence in favour of linkage: 6p22\u201324 (D6S1959: LOD=1.39, <jats:italic>P<\/jats:italic>&lt;0.006), 9p11\u2013q12 (D9S1118: LOD=1.15, <jats:italic>P<\/jats:italic>&lt;0.02), 9q33.2\u201334.3 (D9S915: LOD=1.29, <jats:italic>P<\/jats:italic>&lt;0.01) and 17q11.2 (D17S1294: LOD=1.13, <jats:italic>P<\/jats:italic>&lt;0.02). In single\u2010point analysis, one locus on chromosome 3 close to marker D3S1278 reaches the suggestive level (LOD=2.28, <jats:italic>P<\/jats:italic>&lt;6 \u00d7 10<jats:sup>\u22124<\/jats:sup>) while one on chromosome 17 close to marker D17S921 almost reaches this level (LOD=2.17, <jats:italic>P<\/jats:italic>&lt;8 \u00d7 10<jats:sup>\u22124<\/jats:sup>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t3\">Table 3<\/jats:ext-link>).<\/jats:p><jats:p><jats:table-wrap>\n\n<jats:caption><jats:title>\u2002Single\u2010point linkage analysis for allergic rhinoconjunctivitis<\/jats:title><\/jats:caption>\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:col\/>\n<jats:col\/>\n<jats:col\/>\n<jats:thead>\n<jats:tr>\n<jats:th>Marker<\/jats:th>\n<jats:th>Map position (cM)<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t3n1\"><jats:sup>*<\/jats:sup><\/jats:ext-link><\/jats:th>\n<jats:th>LOD<\/jats:th>\n<jats:th> <jats:italic>P\u2010<\/jats:italic>value<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t3n2\"><jats:sup>\u2020<\/jats:sup><\/jats:ext-link><\/jats:th>\n<\/jats:tr>\n<\/jats:thead>\n<jats:tbody>\n<jats:tr>\n<jats:td>D3S1278<\/jats:td>\n<jats:td>129.73<\/jats:td>\n<jats:td>2.28<\/jats:td>\n<jats:td>&lt;6 \u00d7 10<jats:sup>\u22124<\/jats:sup><\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D3S1267<\/jats:td>\n<jats:td>139.12<\/jats:td>\n<jats:td>1.63<\/jats:td>\n<jats:td>&lt;0.004<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D4S1625<\/jats:td>\n<jats:td>145.98<\/jats:td>\n<jats:td>1.18<\/jats:td>\n<jats:td>&lt;0.01<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D4S1652<\/jats:td>\n<jats:td>208.07<\/jats:td>\n<jats:td>1.77<\/jats:td>\n<jats:td>&lt;0.003<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D6STNFa<\/jats:td>\n<jats:td>63.41<\/jats:td>\n<jats:td>1.14<\/jats:td>\n<jats:td>&lt;0.05<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D9S257<\/jats:td>\n<jats:td>91.87<\/jats:td>\n<jats:td>1.10<\/jats:td>\n<jats:td>&lt;0.05<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D17S921<\/jats:td>\n<jats:td>36.12<\/jats:td>\n<jats:td>2.17<\/jats:td>\n<jats:td>&lt;8 \u00d7 10<jats:sup>\u22124<\/jats:sup><\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D17S1294<\/jats:td>\n<jats:td>50.74<\/jats:td>\n<jats:td>1.78<\/jats:td>\n<jats:td>&lt;0.005<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>D18S843<\/jats:td>\n<jats:td>28.1<\/jats:td>\n<jats:td>1.23<\/jats:td>\n<jats:td>&lt;0.001<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<jats:table-wrap-foot>\n<jats:fn><jats:p>\n                        Position in centiMorgan (cM) of markers from p\u2010ter to q\u2010ter based on the Marshfield map (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http\/\/research.marshfieldclinic.org\/genetics\">http\/\/research.marshfieldclinic.org\/genetics<\/jats:ext-link>).<\/jats:p><\/jats:fn>\n<jats:fn><jats:p>\n                        \n                        <jats:italic>P<\/jats:italic>\u2010values estimated using <jats:italic>P<\/jats:italic> (LOD)=0.5 \u00d7 (\u03c7<jats:sup>2<\/jats:sup><jats:sub>1<\/jats:sub> &gt; 2 ln 10 \u00d7 LOD).<\/jats:p><\/jats:fn>\n<\/jats:table-wrap-foot>\n<\/jats:table-wrap><\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Our results support the linkage to allergic rhinoconjunctivitis on 3q13, 6p23\u2013p24 and 9q34.3 shown in previous investigations.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02397.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T17:55:14Z","timestamp":1137779714000},"page":"204-210","source":"Crossref","is-referenced-by-count":12,"title":["Genome\u2010wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population"],"prefix":"10.1111","volume":"36","author":[{"given":"L. 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