{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:50:24Z","timestamp":1792457424102,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T00:00:00Z","timestamp":1138320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Children allergic to cow's milk are fed a soy\u2010 or a hydrolysed cow's milk\u2010based substitute. Neither can rule out a sensitization risk. Previous studies have shown that hydrolysed rice is tolerated by animals and children with multiple food hypersensitivities.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> A prospective clinical assessment of tolerance to a rice\u2010based hydrolysed formula was carried out in children allergic to cow's milk.<\/jats:p><jats:p><jats:bold>Patients and methods\n\t\t\t\t\t<\/jats:bold> One hundred children (42 girls and 58 boys, mean age 3.17\u00b12.93 years, median 2.20, range 0.18\u201314.6 years) with a history of immediate reactions to cow's milk and confirmed at double\u2010blind, placebo\u2010controlled food challenge (DBPCFC) when not contraindicated were assessed for clinical tolerance to cow's milk proteins. Their allergy work\u2010up included skin prick tests with whole milk, \u03b1\u2010lactalbumin (ALA), \u03b2\u2010lactoglobulin (BLG) and total caseins, and specific IgE determinations using CAP technology were performed against whole milk, ALA, BLG and casein. Sensitization to rice and rice\u2010based hydrolysed formula was similarly investigated. Patients' sera were evaluated at immunoblotting for specific IgE to cow's milk proteins, rice and rice\u2010based hydrolysed formula. DBPCFC was carried out with increasing doses of a rice\u2010based hydrolysed formula.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> All patients were sensitized to cow's milk and\/or at least one cow's milk protein fraction. Eighty\u2010seven out of 99 were positive to cow's milk and\/or a cow's milk protein fraction at skin prick test. Positive (&gt;0.35\u2003kUA\/L) specific IgE determinations were found for cow's milk and\/or milk fractions (92\/95), rice (21\/91) and hydrolysed rice infant formula (4\/91). At immunoblotting, sera from 96 children were positive to \u03b1\u2010casein (<jats:italic>n<\/jats:italic>=54), \u03b2\u2010casein (<jats:italic>n<\/jats:italic>=38), ALA (<jats:italic>n<\/jats:italic>=57), BLG (<jats:italic>n<\/jats:italic>=37) and bovine serum albumin (<jats:italic>n<\/jats:italic>=61). Similarly, although patients' sera often contained specific IgE against rice proteins at CAP (21\/91) and immunoblotting (70\/96), only six very weakly positive responses were observed against rice\u2010based hydrolysed formula. All DBPCFC with rice\u2010based hydrolysed formula were negative.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> Rice\u2010based hydrolysed formula is a possible alternative not only for children with multiple allergies, but also for children with cow's milk allergy.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02428.x","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T14:03:56Z","timestamp":1138370636000},"page":"311-316","source":"Crossref","is-referenced-by-count":52,"title":["A hydrolysed rice\u2010based formula is tolerated by children with cow's milk allergy: a multi\u2010centre study"],"prefix":"10.1111","volume":"36","author":[{"given":"A.","family":"Fiocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Restani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lucarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Magazz\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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