{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:53:19Z","timestamp":1778298799714,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T00:00:00Z","timestamp":1141257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background and objective\n\t\t\t\t\t<\/jats:bold> The <jats:italic>MS4A2<\/jats:italic> gene, the \u03b2 chain of the high\u2010affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. The \u03b2\u2010chain of Fc\u025bR1 enhances receptor maturation and signal transduction capacity, leading to the release of proinflammatory mediators and cytokines that can exacerbate the symptom of asthma. This study was performed to evaluate whether two genetic polymorphisms of the Fc\u025bR1\u03b2 gene (Fc\u025bR1\u03b2\u2212109T&gt;C and Fc\u025bR1\u03b2 E237G) are associated with aspirin\u2010intolerant asthma (AIA).<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> The <jats:italic>MS4A2<\/jats:italic> gene polymorphisms (Fc\u025bR1\u03b2\u2212109T&gt;C and Fc\u025bR1\u03b2 E237G) were determined by SNP\u2010IT\u2122 assays in patients with AIA (<jats:italic>N<\/jats:italic>=164), aspirin\u2010tolerant asthma (ATA, <jats:italic>N<\/jats:italic>=144) and normal controls (NC, <jats:italic>N<\/jats:italic>=264) recruited from a Korean population.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The genotype frequencies of Fc\u025bR1\u03b2\u2212109T&gt;C and E237G polymorphisms were not significantly associated with the pathogenesis of AIA. However, Fc\u025bR1\u03b2\u2212109T&gt;C polymorphism was significantly associated with the presence of specific IgE to <jats:italic>Staphylococcal enterotoxin<\/jats:italic> B (SEB); the number of subjects carrying both homozygous TT genotype of Fc\u025bR1\u03b2\u2212109T&gt;C and specific IgE to SEB was significantly higher in the AIA group when compared with the other control groups (<jats:italic>P<\/jats:italic>=0.01, odds ratio (OR)=7.723, 95% confidence interval (CI)=1.327\u201339.860 for AIA vs. ATA; <jats:italic>P<\/jats:italic>=0.02, OR=6.364, 95% CI=1.149\u223c35.229 for AIA vs. NC). In addition, luciferase reporter assays also showed that the Fc\u025bR1\u03b2\u2212109T allele was associated with higher promoter activity of <jats:italic>MS4A2<\/jats:italic> in both RBL\u20102H3 and A549 cell lines.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Fc\u025bR1\u03b2\u2212109T&gt;C polymorphism may increase expression of <jats:italic>MS4A2<\/jats:italic> by mast cells, leading to enhanced release of proinflammatory mediators in the asthmatic airway, contributing to increased susceptibility to AIA.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02443.x","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T20:14:59Z","timestamp":1141330499000},"page":"877-883","source":"Crossref","is-referenced-by-count":46,"title":["A polymorphism of <i>MS4A2<\/i> (\u2212109T&gt;C) encoding the \u03b2\u2010chain of the high\u2010affinity immunoglobulin E receptor (Fc\u025bR1\u03b2) is associated with a susceptibility to aspirin\u2010intolerant asthma"],"prefix":"10.1111","volume":"36","author":[{"given":"S. \u2010H.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. \u2010S.","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. \u2010T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. \u2010H.","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. \u2010H.","family":"Nahm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. \u2010S.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,2]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"913","article-title":"Aspirin\u2010induced asthma","volume":"111","author":"Szczeklik A","year":"2003","journal-title":"advances in pathogenesis, diagnosis, and management"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90136-5"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92687-1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/383247a0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80203-4"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01209.x"},{"key":"e_1_2_5_8_2","first-page":"1815","article-title":"The cells of the allergic response","volume":"278","author":"Costa JJ","year":"1997","journal-title":"mast cells, basophils, and eosinophils"},{"key":"e_1_2_5_9_2","first-page":"491","article-title":"Human mast cells produce IL\u201013 by high\u2010affinity IgE receptor cross\u2010linking","volume":"102","author":"Toru H","year":"1998","journal-title":"enhanced IL-13 production by IL-4-primed human mast cells"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.8.1129"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7008.776"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91863-9"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02108.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.7.2969-2975.1992"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90383-7"},{"key":"e_1_2_5_16_2","first-page":"289","article-title":"Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in primates","volume":"82","author":"Scheuber PH","year":"1987","journal-title":"the role of endogenous cysteinyl leukotrienes"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00508.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01000.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg055"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4675"},{"key":"e_1_2_5_21_2","first-page":"331","article-title":"Gametic disequilibrium measures","volume":"117","author":"Hedrick PW.","year":"1987","journal-title":"proceed with caution"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80556-7"},{"key":"e_1_2_5_23_2","first-page":"959","article-title":"A new variant of the b subunit of the high\u2010affinity receptor for immunoglobulin E (Fc\u025bRI\u2010b E237G)","volume":"5","author":"Hill MR","year":"1996","journal-title":"associations with measures of atopy and bronchial hyperresponsiveness"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.4.236"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01295.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9903128"},{"key":"e_1_2_5_27_2","first-page":"6458","article-title":"Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity","volume":"173","author":"Nishiyama C","year":"2004","journal-title":"a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/35037021"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.917305.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4532"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200204-291OC"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02051.x"}],"container-title":["Clinical &amp; 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