{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:03Z","timestamp":1791274383611,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T00:00:00Z","timestamp":1143158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> We aimed to assess the prevalence of allergic sensitization and multiple sensitization, risk factors, and the clinical impact of being sensitized in the adult population of Helsinki, Finland.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> As a part of the FinEsS study, a population\u2010based random sample of 498 adults aged 26\u201360 years were tested for 15 common aeroallergens with skin prick tests (SPTs) and interviewed on respiratory symptoms and diseases, including respiratory irritants and childhood environment.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The prevalence of at least one positive prick test was 46.9%. A large difference by age was found: 56.8% were sensitized among those aged 26\u201339 years, 49.2% in the age group 40\u201349 years, and 35.6% in the age group 50\u201360 years (<jats:italic>P<\/jats:italic>&lt;0.001). Sensitization to multiple allergens was common among young subjects with 42% of the sensitized responding to at least four allergens, while this proportion was only 16% of the sensitized among those aged 50\u201360 years. The prevalence of physician\u2010diagnosed asthma, allergic rhinitis (AR) or conjunctivitis, and wheeze increased significantly with increasing number of positive responses to SPTs. Having a family history of AR or conjunctivitis was a significant risk factor for allergic sensitization and for sensitization to any of the pollens. Further, urban living in childhood yielded an increased risk for pollen sensitization.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> The prevalence of allergic sensitization was high in the urban adult population of Helsinki. More than half of those aged 26\u201339 years was sensitized and 24% was sensitized to at least four allergens. Sensitization to multiple allergens was associated with a high prevalence of asthma, AR or conjunctivitis, and wheeze.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02460.x","type":"journal-article","created":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T15:12:57Z","timestamp":1143213177000},"page":"503-509","source":"Crossref","is-referenced-by-count":84,"title":["Degree and clinical relevance of sensitization to common allergens among adults: a population study in Helsinki, Finland"],"prefix":"10.1111","volume":"36","author":[{"given":"P.","family":"Pallasaho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"R\u00f6nmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Haahtela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R. 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