{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:29:19Z","timestamp":1791156559902,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T00:00:00Z","timestamp":1151366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Studies have been performed suggesting that administration of probiotics may have therapeutic and\/or preventive benefits in the development of sensitization and atopic disease, particularly in infants with atopic dermatitis (AD).<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The purpose of this study was to evaluate the clinical and immunological effects of supplementation of a hydrolysed formula with two probiotic strains of bacteria on symptoms of AD in infancy.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> We conducted a randomized, double\u2010blind, placebo\u2010controlled study. After 4\u20136 weeks of baseline and double\u2010blind, placebo\u2010controlled challenges for diagnosis of cow's milk allergy (CMA), infants less than 5 months old with AD received a hydrolysed whey\u2010based formula as placebo (<jats:italic>n<\/jats:italic>=17), or supplemented with either <jats:italic>Lactobacillus rhamnosus<\/jats:italic> (<jats:italic>n<\/jats:italic>=17) or <jats:italic>Lactobacillus GG<\/jats:italic> (<jats:italic>n<\/jats:italic>=16) for 3 months. Before, during and after intervention, the clinical severity of AD was evaluated using SCORing index Atopic Dermatitis (SCORAD). Allergic sensitization was evaluated by measurement of total IgE and a panel of food\u2010specific IgEs as well as skin prick testing for cow's milk. Inflammatory parameters were blood eosinophils, eosinophil protein X in urine, fecal \u03b1\u20101\u2010antitrypsin and production of IL\u20104, IL\u20105 and IFN\u2010\u03b3 by peripheral blood mononuclear cells after polyclonal stimulation.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> No statistically significant effects of probiotic supplementation on SCORAD, sensitization, inflammatory parameters or cytokine production between groups were found. Only four infants were diagnosed with CMA.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> We found no clinical or immunological effect of the probiotic bacteria used in infants with AD. Our results indicate that oral supplementation with these probiotic bacterial strains will not have a significant impact on the symptoms of infantile AD.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02513.x","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T11:14:43Z","timestamp":1151406883000},"page":"899-906","source":"Crossref","is-referenced-by-count":208,"title":["No effects of probiotics on atopic dermatitis in infancy: a randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"36","author":[{"given":"M. L.","family":"Brouwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A. A.","family":"Wolt\u2010Plompen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E. 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