{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:17:13Z","timestamp":1769163433680,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T00:00:00Z","timestamp":1151366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The surfactant protein SP\u2010D has been reported to reduce bronchial hyper\u2010responsiveness, blood eosinophilia, and T\u2010helper type 2 cytokines in models of allergic asthma. However, little is known about the functional effect of SP\u2010D on the early airway response upon allergen inhalation, which is an important feature of this disease.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We investigated whether SP\u2010D is able to reduce the immediate allergen\u2010induced mediator release and the early bronchial obstruction in addition to its effects on airway inflammation and bronchial hyperresponsiveness in an <jats:italic>Aspergillus fumigatus<\/jats:italic> mouse asthma model.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold>  <jats:italic>A. fumigatus<\/jats:italic>\u2010sensitized mice were treated with a recombinant fragment of human SP\u2010D or placebo. Lung functions were measured in orotracheally intubated, spontaneously breathing animals using body plethysmography. In addition, passively sensitized precision\u2010cut lung slices (PCLS) were used to determine the effect of SP\u2010D on allergen\u2010induced histamine release.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> SP\u2010D inhibited the allergen\u2010induced early airway response and reduced airway hyperresponsiveness compared with placebo. Eosinophilia in bronchoalveolar lavage and lung tissue was reduced after SP\u2010D treatment, possibly by reducing eotaxin levels in the lung. Furthermore, SP\u2010D treatment reduced the allergen\u2010induced histamine release from PCLS.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> These data suggest that SP\u2010D not only reduces allergen\u2010induced eosinophilic inflammation and airway hyperresponsiveness but also provides protection against early airway obstruction by inhibition of early mediator release.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02524.x","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T11:14:43Z","timestamp":1151406883000},"page":"930-940","source":"Crossref","is-referenced-by-count":28,"title":["Surfactant protein D inhibits early airway response in <i>Aspergillus fumigatus<\/i>\u2010sensitized mice"],"prefix":"10.1111","volume":"36","author":[{"given":"V. 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