{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:00:13Z","timestamp":1783692013081,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Total immunoglobulin E (IgE) is an important indicator of allergic disorders. However, its role in allergic patients in India has not been evaluated in relation to atopic status for a reference range as compared with healthy subjects.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The aim of the study was to establish serum IgE levels in a diseased group, study its relationship with atopy, and to compare the same with healthy volunteers in Indian subjects.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Four hundred and eighty asthmatics\/allergic patients, 100 first\u2010degree relatives of asthmatics, and 120 unrelated normal healthy volunteers from Delhi region were recruited for the study. Atopy was established by family history and skin test to common indigenous allergens and, total and specific IgE measurements. Statistical analysis was performed with the help of SPSS software program.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The mean IgE levels were the highest in asthmatic patients and the lowest in the control healthy group. IgE was significantly high in the male than the female healthy volunteers (<jats:italic>P<\/jats:italic>&lt;0.05), but not in the diseased group. <jats:italic>Prosopis juliflora<\/jats:italic> among pollen allergens and <jats:italic>Alternaria alternata<\/jats:italic> among fungal allergens were important sensitizers in allergic patients with 34.7% and 17.7% skin positivity, respectively. Atopic status and asthma were found to be the best predictor of IgE, which was highly significant (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>=0.239, <jats:italic>P<\/jats:italic>&lt;0.00001). However, at 95% confidence interval as many as 50% of asthmatic patients had their IgE values in the normal range.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> The IgE levels in Indian allergic patients is significantly related to atopy, but due to wide overlap of IgE levels in patients and healthy subjects, its diagnostic significance in Indian population seems to be limited.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02525.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T01:28:37Z","timestamp":1152235717000},"page":"1019-1027","source":"Crossref","is-referenced-by-count":38,"title":["Total serum immunoglobulin E levels in a case\u2013control study in asthmatic\/allergic patients, their family members, and healthy subjects from India"],"prefix":"10.1111","volume":"36","author":[{"given":"S.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Kathuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nordling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"849","volume-title":"Allergy: Principles and Practices","author":"Yunginger JW.","year":"1988"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236438"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70110-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09091880"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1982.tb02346.x"},{"key":"e_1_2_6_7_2","first-page":"547","article-title":"Diagnosis of atopic conditions in the tropics","volume":"51","author":"Lynch NR","year":"1983","journal-title":"Ann Allergy"},{"key":"e_1_2_6_8_2","first-page":"108","article-title":"Definition, incidence, etiology and natural history of asthma","volume":"6","author":"Vishwananthan R.","year":"1964","journal-title":"Ind J Chest Dis"},{"key":"e_1_2_6_9_2","first-page":"131","article-title":"Aeroallergens in clinical practice of allergy in India. An overview","volume":"10","author":"Singh AB","year":"2003","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00463.x"},{"key":"e_1_2_6_11_2","volume-title":"Delhi and its neighbourhood","author":"Sharma YD","year":"1990"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.225"},{"key":"e_1_2_6_13_2","first-page":"673","article-title":"Determinants of bronchial responsiveness in the European Community Respiratory Health Survey in Italy","volume":"53","author":"ECRHS.","year":"1998","journal-title":"evidence of an independent role of atopy, total serum IgE levels and asthma symptoms"},{"key":"e_1_2_6_14_2","first-page":"103","article-title":"Biological standardization of pollen allergens from India","volume":"10","author":"Singh AB","year":"1992","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70372-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1979.tb02494.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880200030004"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.03403.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90114-1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1981.tb01871.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200502"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00050.x"},{"key":"e_1_2_6_23_2","first-page":"308","article-title":"Epidemiology of immunoglobulin E levels in a defined population","volume":"64","author":"Criqui MH","year":"1990","journal-title":"Ann Allergy"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90026-3"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90089-2"},{"key":"e_1_2_6_26_2","first-page":"30","article-title":"Discriminant analysis in allergic rhinitis and asthma","volume":"97","author":"Alvarez\u2010Puebla MJ","year":"2003","journal-title":"methacholine dose-response slope allows a good differentiation between mild asthma and rhinitis"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb00703.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb03255.x"},{"key":"e_1_2_6_29_2","first-page":"331","article-title":"Serum IgE levels","volume":"31","author":"Loeffler JA","year":"1973","journal-title":"correlation with skin test sensitivity"},{"key":"e_1_2_6_30_2","first-page":"106","article-title":"Distribution of IgE in a community population sample","volume":"68","author":"Barbee RA","year":"1981","journal-title":"correlations with age, sex and allergen skin test reactivity"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb00669.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62835-9"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200502"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9708064"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02734234"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237116"},{"key":"e_1_2_6_37_2","first-page":"67","article-title":"Intestinal geohelminthiasis in the developing world","volume":"10","author":"Ananthakrishnan S","year":"1997","journal-title":"Natl Med J India"},{"key":"e_1_2_6_38_2","first-page":"492","article-title":"Intestinal helminthic infestation in children","volume":"46","author":"Chandrasekhar MR","year":"2003","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_6_39_2","first-page":"35","article-title":"A comparative study of intestinal parasites prevalent among children living in rural and urban settings in and around Chennai","volume":"34","author":"Fernandez MC","year":"2002","journal-title":"J Commun Dis"},{"key":"e_1_2_6_40_2","first-page":"104","article-title":"Parasitic gut flora in a North Indian population with gastrointestinal symptoms","volume":"14","author":"Singh S","year":"1993","journal-title":"Trop Gastroenterol"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2006.02525.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2006.02525.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:02:19Z","timestamp":1697421739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2006.02525.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,4]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1365-2222.2006.02525.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2006.02525.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,4]]}}}