{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:42:52Z","timestamp":1791960172849,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The role of bacterial enterotoxins like <jats:italic>Staphylococcus aureus<\/jats:italic> enterotoxin B (SEB) in allergic asthma remains unknown. We used a mouse model of airway allergy to study the effects of nasal or bronchial contact with SEB on bronchial allergic inflammation.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> The features of allergic asthma were induced in ovalbumin (OVA)\u2010sensitized mice (days 1\u201313) by repeated exposures to nebulized OVA (days 33\u201337). Nasal or bronchial application of SEB was performed on three occasions (days 33\u201335\u201337), and the effects on bronchial inflammation, IgE titres and expression levels of mRNA for T helper type 2 cytokines and other inflammatory mediators were evaluated.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Both nasal and bronchial SEB enhanced the allergen\u2010induced bronchial inflammation, as reflected by more eosinophilic inflammation in the airway lumen and in bronchial tissue. Aggravation of experimental asthma correlated with higher expression of mRNA for IL\u20105, IL\u20104, IFN\u2010\u03b3, IL\u201012 p40, eotaxin\u20101 and TGF\u2010\u03b2 in bronchi. In addition, nasal SEB elevated concentrations of IL\u20104, IL\u20105 and IFN\u2010\u03b3 in serum and bronchial SEB increased titres of OVA\u2010specific and total IgE in serum.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Our data illustrate the potential of both nasal as well as bronchial SEB to aggravate several features of allergic asthma in a mouse model.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02527.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T01:28:37Z","timestamp":1152235717000},"page":"1063-1071","source":"Crossref","is-referenced-by-count":56,"title":["Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to <i>Staphylococcus aureus<\/i> enterotoxin B"],"prefix":"10.1111","volume":"36","author":[{"given":"P. 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