{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:52:06Z","timestamp":1789869126397,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> High serum levels of cat\u2010specific IgG and IgG4 are associated with protection against allergic sensitization to cat, but whether this association applies to other animal allergens remains unclear.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To determine if high levels of mouse\u2010specific IgG and IgG4 are associated with a decreased risk of mouse skin test sensitivity.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Two hundred and sixty workers of a mouse facility underwent skin prick testing and completed a questionnaire. Serum levels of mouse\u2010specific IgG and IgG4 were quantified by solid\u2010phase antigen binding assays. Room air samples were collected and airborne Mus m 1 was quantified by ELISA.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Forty\u2010nine participants had a positive skin prick test to mouse. Mouse\u2010specific IgG was detected in 219 (84%) participants and IgG4 was detected in 72 (28%) participants. A detectable mouse\u2010specific IgG4 level was associated with an increased risk of mouse skin test sensitivity (odds ratios (OR) 6.4, 95% confidence intervals (CI) 3.3\u201312.4). Mouse\u2010specific IgG and IgG4 were both positively correlated with mouse allergen exposure (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>=0.31, <jats:italic>P<\/jats:italic>=0.0001, and <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>=0.27, <jats:italic>P<\/jats:italic>=0.0006, respectively). The odds of skin test sensitivity peaked at moderate levels of IgG4, but decreased at the highest levels of mouse\u2010specific IgG4. In contrast, the odds of skin test sensitivity increased monotonically with IgG levels.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> A detectable level of mouse\u2010specific IgG4 is associated with an increased risk of skin test sensitivity to mouse. However, the highest IgG4 levels appear to be associated with an attenuated risk of mouse skin test sensitivity, suggesting that induction of high levels of IgG4 through natural exposure may protect against the development of allergic sensitization.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02534.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T01:28:37Z","timestamp":1152235717000},"page":"1097-1103","source":"Crossref","is-referenced-by-count":25,"title":["Mouse allergen\u2010specific immunoglobulin G4 and risk of mouse skin test sensitivity"],"prefix":"10.1111","volume":"36","author":[{"given":"E. C.","family":"Matsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. B.","family":"Diette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J. M.","family":"Krop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Aalberse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Eggleston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110796"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110795"},{"key":"e_1_2_5_4_2","first-page":"171","article-title":"Mouse allergen exposure and immunologic responses","volume":"93","author":"Matsui EC","year":"2004","journal-title":"IgE-mediated mouse sensitization, mouse-specific IgG and IgG4 levels"},{"key":"e_1_2_5_5_2","first-page":"43","article-title":"Microenvironment in ventilated animal cages with differing ventilation rates, mice populations, and frequency of bedding changes","volume":"37","author":"Reeb C","year":"1998","journal-title":"Contemp Top Lab Anim Sci"},{"key":"e_1_2_5_6_2","first-page":"74","article-title":"Impact of room ventilation rates on mouse cage ventilation and microenvironment","volume":"36","author":"Reeb CK","year":"1997","journal-title":"Contemp Top Lab Anim Sci"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70537-3"},{"key":"e_1_2_5_8_2","first-page":"752","article-title":"Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen","volume":"357","author":"Platts\u2010Mills T","year":"2001","journal-title":"a population-based cross-sectional study"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2003.01821.x"},{"key":"e_1_2_5_10_2","first-page":"271","article-title":"Mechanisms of tolerance to inhalant allergens","volume":"25","author":"Platts\u2010Mills TA","year":"2004","journal-title":"the relevance of a modified Th2 response to allergens from domestic animals"},{"key":"e_1_2_5_11_2","first-page":"1","article-title":"Epidemiology Standardization Project (American Thoracic Society)","volume":"118","author":"Ferris BG.","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70289-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237265"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi026423q"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90147-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01127.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02025.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2763"},{"key":"e_1_2_5_19_2","first-page":"171","article-title":"Mouse allergen exposure and immunologic responses","volume":"93","author":"Matsui EC","year":"2004","journal-title":"IgE-mediated mouse sensitization and mouse specific IgG and IgG4 levels"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2006.02534.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2006.02534.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:01:59Z","timestamp":1697421719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2006.02534.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,4]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1365-2222.2006.02534.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2006.02534.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,4]]}}}