{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:50:33Z","timestamp":1763967033268},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> It is well known that atopy is a major determinant of bronchial hyper\u2010responsiveness (BHR) in both asymptomatic and asthmatic children. However, the relationship between atopy and BHR has not been well studied in preschool children with wheezing. BHR is usually measured by bronchial challenges using direct and indirect stimuli.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The aim of this study was to investigate whether atopic and non\u2010atopic preschool wheezers display similar or different BHR profiles for direct and indirect stimuli.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Methacholine and adenosine 5\u2032\u2010monophosphate (AMP) bronchial challenges were performed in 4 to 6\u2010year\u2010old children with recurrent wheezing, using a modified auscultation method. The end\u2010point was defined as the appearance of wheezing and\/or oxygen desaturation. Atopy was determined to be present when a child had at least one positive reaction to a panel of 13 common airborne allergens in the presence of positive and negative controls.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> A positive response to methacholine (an end\u2010point concentration 8\u2003mg\/mL) was observed in 89.3% (50\/56) of atopic wheezers and in 83.8% (31\/37) of non\u2010atopic wheezers (<jats:italic>P<\/jats:italic>=0.44) for the difference. By contrast, the frequency of a positive response to AMP (an end\u2010point concentration 200\u2003mg\/mL) was significantly higher in the atopic group (47\/56, 83.9%) compared with the non\u2010atopic group (12\/37, 32.4%; <jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> While a majority of both atopic and non\u2010atopic preschool wheezers were hyper\u2010responsive to methacholine, atopic subjects were more hyper\u2010responsive to AMP than non\u2010atopic subjects. These findings suggest that atopic and non\u2010atopic wheeze in preschool children are related to distinctive pathophysiologic pathways.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02557.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:50:20Z","timestamp":1166687420000},"page":"15-21","source":"Crossref","is-referenced-by-count":12,"title":["Bronchial responsiveness to methacholine and adenosine 5\u2032\u2010monophosphate in atopic and non\u2010atopic preschool children with recurrent wheezing"],"prefix":"10.1111","volume":"37","author":[{"given":"D. K.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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