{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:52:07Z","timestamp":1777927927367,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Epidemiological data on the prevalence and risk factors of latex sensitization have suggested a significant association between latex sensitization and the presence of one or more positive skin prick test responses to aeroallergens, food allergens and to one or more insect venoms. Xylose and core 3\u2010fucose are typical complex glycans in plants and are foreign to mammals. Plant <jats:italic>N<\/jats:italic>\u2010glycans and insect <jats:italic>N<\/jats:italic>\u2010glycans may cross\u2010react in humans.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The aim of our study was to investigate whether there are cross\u2010reactive IgE\u2010binding structures in natural rubber latex (NRL) and hymenoptera venoms and to examine their nature.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Hundred and twenty\u2010five consecutive patients with insect venom allergy were screened for coincidental latex\u2010specific IgE. IgE\u2010binding components in the venoms from <jats:italic>Apis mellifera<\/jats:italic> and\/or vespula species and in NRL extracts were characterized by IgE\u2010immunoblotting to the natural allergen sources and determination of specific IgE to recombinant allergens. Cross\u2010reactive components were investigated by inhibition experiments. The involvement of carbohydrates in the constitution of cross\u2010reactive IgE\u2010epitopes was further examined by specific IgE\u2010binding to cross\u2010reactive carbohydrate determinants (CCD) in bromelain and horseradish peroxidase as well as by periodate treatment.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> NRL glove extracts inhibited patients' serum IgE\u2010binding to venom allergens. Vice versa, the IgE\u2010binding to latex glove extracts could be inhibited by pre\u2010incubation with the insect venoms. Specific IgE\u2010binding to recombinant latex allergens was absent, whereas the cross\u2010reactive IgE\u2010epitopes were sensitive to periodate treatment and specific IgE to CCD (MMXF and MUXF type) could be detected.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Insect venoms and NRL share IgE\u2010binding CCD that may be responsible for positive serological test results to NRL in patients with insect venom allergy. This copositivity occurs frequently (13.6%) among venom\u2010allergic individuals and did not elicit clinical symptoms upon contact to latex in the patients examined. In contrast, true cosensitization to insect venoms and NRL allergens can occur and may not be missed.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02587.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T20:14:38Z","timestamp":1162498478000},"page":"1446-1456","source":"Crossref","is-referenced-by-count":39,"title":["Natural rubber latex and hymenoptera venoms share ImmunoglobinE\u2010epitopes accounting for cross\u2010reactive carbohydrate determinants"],"prefix":"10.1111","volume":"36","author":[{"given":"V.","family":"Mahler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gutgesell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Valenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000023930"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106925"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70169-1"},{"issue":"2","key":"e_1_2_6_5_2","first-page":"S61","article-title":"Kreuzreaktionen bei Insektengift\u2010Allergie","volume":"22","author":"Gutgesell C","year":"1999","journal-title":"Allergologie"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70249-5"},{"key":"e_1_2_6_7_2","first-page":"404","article-title":"Latex fruit syndrome","volume":"52","author":"Brehler R","year":"1997","journal-title":"frequency of cross-reacting IgE antibodies"},{"key":"e_1_2_6_8_2","first-page":"137","article-title":"Sensitization to cross\u2010reactive carbohydrate determinants and the ubiquitous protein profilin","volume":"34","author":"Ebo DG","year":"2004","journal-title":"mimickers of allergy"},{"key":"e_1_2_6_9_2","first-page":"78","article-title":"Diagnose und Therapie der Bienen\u2010 und Wespengiftallergie","volume":"24","author":"Rueff F","year":"2001","journal-title":"Allergologie"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770906609106941"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70099-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00721.x"},{"issue":"10","key":"e_1_2_6_13_2","first-page":"31","article-title":"Skin tests for the diagnosis of IgE\u2010mediated allergy","volume":"44","author":"Dreborg S.","year":"1989","journal-title":"Allergy"},{"key":"e_1_2_6_14_2","unstructured":"FuchsT.Gummi und Allergie. 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