{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:55:26Z","timestamp":1774288526914,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> A considerable proportion of animal\u2010allergic patients are sensitized to both cat and dog allergens but knowledge about cross\u2010reactive allergens in cat and dog dander is limited.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To investigate whether dog dander contains an allergen that cross\u2010reacts with the major cat allergen, Fel d 1.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Recombinant Fel d 1 with the same immunological properties as natural Fel d 1 was used for quantitative (CAP) IgE competition experiments performed with sera obtained from cat\u2010allergic patients (<jats:italic>n<\/jats:italic>=36). A Fel d 1 cross\u2010reactive dog allergen was characterized by one\u2010 and two\u2010dimensional immunoblotting using rFel d 1 for IgE inhibition experiments and with monospecific, polyclonal rabbit anti\u2010recombinant Fel d 1 antibodies.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> In 25% of Fel d 1\u2010reactive cat\u2010allergic patients, more than 50% inhibition of IgE reactivity to dog allergens was achieved with recombinant Fel d 1. An Fel d 1 cross\u2010reactive 20\u2003kDa allergen with a pI of approximately 3.4 was detected in dander extracts of several different dog breeds.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> This is the first report demonstrating the presence of an Fel d 1\u2010like allergen in dog dander extracts, which may be responsible for double positivity to cat and dog in serology. However, the clinical relevance of this cross\u2010sensitization needs to be confirmed. These results are important for the diagnostic and therapeutic use of dog dander allergen extracts.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02611.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:50:20Z","timestamp":1166687420000},"page":"116-124","source":"Crossref","is-referenced-by-count":40,"title":["Detection of an allergen in dog dander that cross\u2010reacts with the major cat allergen, Fel d 1"],"prefix":"10.1111","volume":"37","author":[{"given":"R.","family":"Reininger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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