{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:14:33Z","timestamp":1697271273644},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Airway challenge of ovalbumin\u2010sensitized mice induces intrapulmonary accumulation of eosinophil progenitors.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To evaluate whether allergen\u2010challenged lungs release factors promoting intrapulmonary accumulation of haemopoietic cells, and define the role of allergic lung injury, we developed a transplantation model.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Lung tissue from allergen\u2010challenged, sensitized donors was ectopically grafted in syngeneic recipients, and haemopoietic progenitors inside the lungs of the recipients were quantified.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> In BALB\/c mice, accumulation of progenitors occurred only when: (a) donors were sensitized and airway challenged with homologous allergen; (b) and recipients were sensitized. Grafts from the appropriate donors released biologically active IL\u20105, which was effective in sensitized recipients. The effect of the appropriate donor\u2013recipient combination was prevented by neutralizing anti\u2010IL\u20105 antibody. Grafts from unchallenged, sensitized donors synergized with recombinant IL\u20105 in sensitized recipients. Unlike BALB\/c, grafts from na\u00efve IL\u20105 transgenic CBA\/Ca mice (whose lungs contained a large number of progenitors, independently of sensitization and challenge) were effective in non\u2010transgenic, ovalbumin\u2010sensitized recipients.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> This shows that: (a) intrapulmonary accumulation of progenitors is independent of immunological injury; (b) grafts systemically release IL\u20105, which is required for progenitor accumulation in the recipients' lungs; (c) and sensitization is required for full responsiveness to IL\u20105 and for generation of lung\u2010derived signals that synergize with IL\u20105.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02623.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T13:33:49Z","timestamp":1164720829000},"page":"29-38","source":"Crossref","is-referenced-by-count":7,"title":["Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients' lungs through an allergen\u2010 and interleukin\u20105\u2010dependent mechanism"],"prefix":"10.1111","volume":"37","author":[{"given":"P.","family":"Xavier\u2010Elsas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Santos\u2010Maximiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Queto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mendon\u00e7a\u2010Sales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. I. C.","family":"Gaspar\u2010Elsas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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