{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:56:49Z","timestamp":1791115009558,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Sublingual immunotherapy (SLIT) is a clinically effective treatment in both pollen and house dust mite\u2010induced rhinitis and asthma. However, the mechanisms by which this is accomplished are not clear.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The objective of the current study was to establish a mouse model of rhinitis in order to study the effect and mechanisms of SLIT.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Mice were sensitized by intraperitoneal injections of alum\u2010adsorbed <jats:italic>Phleum pratense<\/jats:italic> extract. Sensitized mice were SLIT\u2010treated and subsequently challenged intranasally and analysed for clinical symptoms, antibody levels, eosinophilia and T cell response.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Intranasal challenge of sensitized mice led to the development of rhinitis characterized by significantly increased sneezing and influx of eosinophils into the nose. Levels of specific IgE were fivefold increased in nasopharyngeal lavage (NAL) fluid and more than doubled in serum. Furthermore, a T\u2010helper type 2 (Th2) like T cell response was observed in local draining lymph nodes. SLIT treatment of sensitized mice reduced sneezing, eosinophilia and IgE levels in the NAL by more than 50%. Moreover, serum levels of IgE and IgG1 as well as T cell response in the draining lymph nodes were also significantly reduced. Treatment for a shorter time or with a lower dose only led to minor reductions of the clinical and immunological parameters, indicating that the effect of SLIT is time and dose dependent.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> In the present study, we have established a mouse model displaying the hallmarks of allergic rhinitis using a clinically relevant allergen. Using this model, we have demonstrated that SLIT treatment is able to reduce allergic symptoms in a time\u2010 and dose\u2010dependent manner.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02624.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T13:33:49Z","timestamp":1164720829000},"page":"488-497","source":"Crossref","is-referenced-by-count":56,"title":["Sublingual immunotherapy reduces allergic symptoms in a mouse model of rhinitis"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Brimnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kildsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440106"},{"key":"e_1_2_6_3_2","first-page":"520","article-title":"Burden of allergic disease in the UK","volume":"34","author":"Gupta R","year":"2004","journal-title":"secondary analyses of national databases"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7134.843"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200423595"},{"key":"e_1_2_6_6_2","first-page":"558","article-title":"Allergen immunotherapy","volume":"102","author":"Bousquet J","year":"1998","journal-title":"therapeutic vaccines for allergic diseases. 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