{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:21:08Z","timestamp":1791228068378,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Continuous oral administration of live <jats:italic>Lactobacillus rhamnosus<\/jats:italic> GG (<jats:italic>L<\/jats:italic>. GG) to pregnant subjects with atopic dermatitis and their children, suppressed the frequency of atopic dermatitis. The details of mechanisms and immune systems involved in this suppressive effect, however, remain speculative.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We sought to clarify suppressive mechanisms of <jats:italic>L<\/jats:italic>. GG on atopic dermatitis by using NC\/Nga mice, a model of human atopic dermatitis.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Maternal mice and infant mice were fed with food containing or not containing heat\u2010treated <jats:italic>L<\/jats:italic>. GG during pregnancy and breastfeeding, and after weaning.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Control NC\/Nga mice raised under an air\u2010uncontrolled condition spontaneously manifested typical skin lesions very similar to those in patients with atopic dermatitis. On the other hand, administration of food containing heat\u2010treated <jats:italic>L<\/jats:italic>. GG inhibited the onset and development of atopic skin lesions, accompanied by smaller numbers of mast cells and eosinophils in the affected skin sites. Mice fed with <jats:italic>L<\/jats:italic>. GG showed a significant increase in plasma IL\u201010 levels compared with control mice, while there was no significant difference in the proportion of splenic CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> regulatory T cells between mice fed with <jats:italic>L<\/jats:italic>. GG and control mice. The IL\u201010 mRNA expression was enhanced in both Peyer's patches and mesenteric lymph nodes in mice fed with <jats:italic>L<\/jats:italic>. GG.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> These findings suggest that some components of heat\u2010treated <jats:italic>L<\/jats:italic>. GG may have an ability to delay the onset and suppress the development of atopic dermatitis, probably through a strong induction of IL\u201010 in intestinal lymphoid organs and systemic levels.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2006.02645.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T05:46:32Z","timestamp":1166679992000},"page":"296-303","source":"Crossref","is-referenced-by-count":92,"title":["Ingestion of heat\u2010treated <i>Lactobacillus rhamnosus<\/i> GG prevents development of atopic dermatitis in NC\/Nga 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