{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:29:07Z","timestamp":1792250947392,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T00:00:00Z","timestamp":1175731200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    There are few published studies on geographical variation in prevalence of eczema in adults or its association with recognised risk factors for allergic disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    To describe the geographical variation in prevalence of eczema in adults, assess the associations with sociodemographic risk factors, serum\u2010specific IgE and IgG, and exposure to allergen.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    A community\u2010based sample of 8206 adults aged 27\u201356 years, in 25 European centres and Portland, USA, provided questionnaire information on symptoms of eczema. Serum\u2010specific IgE to house dust mite (HDM), cat, grass and\n                    <jats:italic>Cladosporium<\/jats:italic>\n                    , and IgG and IgG4 to HDM and cat were measured. Mattress levels of mite and cat allergen were assessed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    Overall prevalence of eczema was 7.1% (range between countries of 2.2\u201317.6%). Eczema was associated with female gender [odds ratio (OR) 1.25; 95% confidence interval (CI) (1.01\u20131.55)], family history of atopic disease (OR 1.43; 95% CI 1.18\u20131.74), IgE sensitization to at least one allergen (OR 1.50; 95% CI 1.19\u20131.90), particularly\n                    <jats:italic>Cladosporium<\/jats:italic>\n                    (OR 3.65; 95% CI 1.81\u20137.37), and total IgE. Eczema was negatively associated with age and no clear associations were observed with sibship size, mattress mite and cat allergen levels or with cat and HDM\u2010specific IgG or IgG4.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    There is geographical variation in the prevalence of eczema in adults both within and between countries. Although the disease is associated with IgE sensitization, in this study it was not related to mattress mite or cat allergen levels.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02679.x","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T19:25:57Z","timestamp":1175801157000},"page":"526-535","source":"Crossref","is-referenced-by-count":133,"title":["Eczema, atopy and allergen exposure in adults: a population\u2010based study"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Harrop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Verlato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Norb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wjst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Janson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Zock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Leynaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gislason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ponzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Svanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,5]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"832","article-title":"Revised nomenclature for allergy for global use","volume":"113","author":"Johansson SG","year":"2004","journal-title":"report of the nomenclature review committee of the world allergy organization, October 2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70536-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62852-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545771","volume-title":"Atopic dermatitis \u2013 the epidemiology, causes, and prevention of atopic eczema","author":"Williams HC.","year":"2000"},{"key":"e_1_2_6_6_2","first-page":"1301","article-title":"Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis","volume":"35","author":"Zutavern A","year":"2005","journal-title":"results from a cross-sectional study"},{"key":"e_1_2_6_7_2","first-page":"520","article-title":"Burden of allergic disease in the UK","volume":"34","author":"Gupta R","year":"2004","journal-title":"secondary analyses of national databases"},{"key":"e_1_2_6_8_2","first-page":"107","article-title":"Skin disease in Lambeth. 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