{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:02Z","timestamp":1791156482661,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T00:00:00Z","timestamp":1179360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Peanut (PN)\u2010anaphylaxis is potentially life threatening. We previously reported that a Chinese herbal medicine preparation, food allergy herbal formula\u20102 (FAHF\u20102), prevented peanut allergy (PNA) in mice when administered during sensitization.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To investigate whether FAHF\u20102 also can prevent anaphylactic reactions when administered to mice with established PNA and, if so, whether protection would persist after cessation of therapy.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> C3H\/HeJ mice sensitized and boosted over 8 weeks with a standard protocol known to establish PN hypersensitivity received seven weeks of FAHF\u20102 treatment or water as a sham treatment. Mice were subsequently challenged with PN at week 14 (1\u2010day post\u2010therapy) and week 18 (4\u2010week post\u2010therapy) to evaluate the efficacy and persistence of FAHF\u20102 treatment by assessing anaphylactic scores, core body temperatures and plasma histamine levels. Serum PN\u2010specific antibody levels and cytokine profiles from splenocytes and mesenteric lymph node (MLN) cells were also determined.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> All sham\u2010treated mice challenged at weeks 14 and 18 showed anaphylactic symptoms. In contrast, FAHF\u20102\u2010treated mice showed no sign of anaphylactic reactions. PN\u2010specific IgE levels in FAHF\u20102\u2010treated mice also were reduced whereas IgG2a levels were increased. Furthermore, MLN cells from FAHF\u20102\u2010treated mice produced markedly less IL\u20104 and IL\u20105, but more IFN\u2010\u03b3, and contained increased numbers of IFN\u2010\u03b3\u2010producing CD8<jats:sup>+<\/jats:sup> cells as compared with sham\u2010treated mice.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> FAHF\u20102 treatment established PN tolerance in this model, which persisted for at least 4\u2010week post\u2010treatment. This result was associated with modulation of intestinal T helper type 1 cell (Th1) and Th2 cytokine production, and with increased numbers of mesenteric IFN\u2010\u03b3\u2010producing CD8<jats:sup>+<\/jats:sup> cells.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02718.x","type":"journal-article","created":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T23:56:29Z","timestamp":1179446189000},"page":"846-855","source":"Crossref","is-referenced-by-count":80,"title":["Induction of tolerance after establishment of peanut allergy by the food allergy herbal formula\u20102 is associated with up\u2010regulation of interferon\u2010\u03b3"],"prefix":"10.1111","volume":"37","author":[{"given":"C.","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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