{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:10:58Z","timestamp":1780567858905,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,15]],"date-time":"2007-06-15T00:00:00Z","timestamp":1181865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Adipokines are involved in the regulation of many inflammatory processes and are present at very high concentrations in cord blood of term infants.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We analysed data of a large prospective birth cohort study to examine whether adiponectin and leptin concentration in cord blood are determinants of wheezing disorders in children within the first 2 years of life.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Seven hundred and forty mothers and their newborns were included in this analysis. Adiponectin and leptin concentrations were measured in cord blood. The cumulative incidence of physician\u2010reported asthma or obstructive bronchitis was recorded during a 2\u2010year follow\u2010up.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> During the first 2 years of life, asthma or obstructive bronchitis was reported by the caring paediatricians for 157 (19.6%) of the children. We found a strong interaction of cord blood adiponectin and history of atopic disease in the mother with respect to the risk of physician\u2010reported asthma or obstructive bronchitis (<jats:italic>P<\/jats:italic>=0.006). Compared with children with cord blood levels in the middle quintile (reference category), the odds ratios for physician\u2010reported asthma or obstructive bronchitis in the bottom quintile and top quintile were 0.14 [95% confidence interval (CI) 0.02\u20130.90] and 2.12 (95% CI 0.67\u20136.66), respectively (<jats:italic>P<\/jats:italic> for trend=0.0003), among children of mothers with a history of atopy. This association was independent of other established risk factors. Leptin levels in cord blood were not associated with risk of asthma or obstructive bronchitis.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> In children of mothers with a history of atopy, concentrations of adiponectin in cord blood could play an important role in determining risk of wheezing disorders in early childhood.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02759.x","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T13:31:25Z","timestamp":1182000685000},"page":"1143-1149","source":"Crossref","is-referenced-by-count":31,"title":["Adipokines in cord blood and risk of wheezing disorders within the first two years of life"],"prefix":"10.1111","volume":"37","author":[{"given":"D.","family":"Rothenbacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Weyermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fantuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6705.946"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.042"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2271"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.023"},{"key":"e_1_2_6_7_2","first-page":"4031","article-title":"Cord plasma adiponectin","volume":"89","author":"Kajantie E","year":"2004","journal-title":"a 20-fold rise between 24 weeks gestation and term"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm788"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1301\/002966402320634878"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0492-1"},{"key":"e_1_2_6_11_2","first-page":"254","article-title":"Leptin","volume":"114","author":"Guler N","year":"2004","journal-title":"does it have any role in childhood asthma?"},{"key":"e_1_2_6_12_2","first-page":"332","article-title":"The mother as intrafamilial source of Helicobacter pylori infection","volume":"17","author":"Weyermann M","year":"2006","journal-title":"a prospective birth cohort study"},{"key":"e_1_2_6_13_2","first-page":"5656","article-title":"Adiponectin in human cord blood","volume":"88","author":"Sivan E","year":"2003","journal-title":"relation to fetal birth weight and gender"},{"key":"e_1_2_6_14_2","first-page":"521","article-title":"Hyperadiponectinemia in newborns","volume":"12","author":"Pardo IM","year":"2004","journal-title":"relationship with leptin levels and birth weight"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.071019"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200312-1647OC"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00931.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-044AW"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200010)62:2<257::AID-JMV19>3.0.CO;2-M"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5958"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.4.917"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi340"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.021"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6705.946"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2007.02759.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2007.02759.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:56:07Z","timestamp":1697374567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2007.02759.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,3]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1365-2222.2007.02759.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2007.02759.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,3]]}}}