{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:41:29Z","timestamp":1775011289350,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:00:00Z","timestamp":1182729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> There is a difference in the extent of remodelling in allergic rhinitis (AR) and asthma. This may be attributed to the difference in local tissue response to these mediators.<\/jats:p><jats:p><jats:bold>Objectives\n\t\t\t\t\t<\/jats:bold> The aim of this study was to compare vascular endothelial growth factor (VEGF) and its receptor foetal liver kinase (Flk)\u20101 expression between seasonal AR patients with or without asthma and non\u2010allergic controls as well as that between AR patients with and without asthma.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Thirteen subjects with seasonal AR and six non\u2010allergic controls were included in the study. Allergic sensitization was demonstrated by a skin prick test. Inferior turbinate thiny biopsies were obtained from both groups. Monoclonal mouse antibodies were used to demonstrate VEGF and Flk\u20101. Nasal mucosal endothelial cells' staining intensity was graded semi\u2010quantitatively and the histochemical score (HSCORE) was calculated. In all samples, VEGF\u2010 and Flk\u20101\u2010labelled vessels were counted for the assessment of vascular surface density (VSD).<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The mean HSCORE for VEGF and anti\u2010VEGF\u2010based VSD were significantly higher in the patient group (<jats:italic>P<\/jats:italic>=0.001 and 0.002, respectively). The mean HSCORE for Flk\u20101 and anti\u2010Flk\u20101\u2010based VSD in the patient group were significantly higher than those in the control group (<jats:italic>P<\/jats:italic>=0.016 and 0.028, respectively). Differences between the mean HSCORE for VEGF and anti\u2010VEGF\u2010based VSD in patients with pure AR and AR and asthma were insignificant (<jats:italic>P<\/jats:italic>=0.16 and 0.39, respectively). The mean HSCORE for Flk\u20101 and anti\u2010Flk\u20101\u2010based VSD in patients with pure AR were significantly lower than those in patients with AR and asthma (<jats:italic>P<\/jats:italic>=0.004 and 0.018, respectively).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Angiogenic factor VEGF and its receptor Flk\u20101 is increased in AR. A similar increase in VEGF in AR with and without asthma despite a higher Flk\u20101 in AR patients with asthma may be a possible explanation for the presence of angiogenesis in the airway wall in patients with asthma but not in those with pure AR.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02763.x","type":"journal-article","created":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T11:19:33Z","timestamp":1182770373000},"page":"1183-1188","source":"Crossref","is-referenced-by-count":17,"title":["Increased expression of tissue vascular endothelial growth factor and foetal liver kinase\u20101 receptor in seasonal allergic rhinitis and relevance to asthma component"],"prefix":"10.1111","volume":"37","author":[{"given":"H.","family":"Yuksel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ozbilgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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