{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:01:08Z","timestamp":1768870868309,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,9,17]],"date-time":"2007-09-17T00:00:00Z","timestamp":1189987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Assessment of allergic sensitization is not routinely performed in infants and young children with eczema.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To determine whether infants who have atopic eczema (with sensitization) are at a greater risk of developing asthma and allergic rhinitis (AR) than those with non\u2010atopic eczema (without concurrent sensitization).<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> The presence of eczema was prospectively documented until 2 years of age in a birth cohort of 620 infants with a family history of atopic disease. Sensitization status was determined by skin prick tests (SPTs) at 6, 12, and 24 months using six common allergens. Interviews were conducted at 6 and 7 years to determine the presence of asthma and AR.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Within the first 2 years of life, 28.7% of the 443 children who could be classified had atopic eczema: 20.5% had non\u2010atopic eczema, 19.0% were asymptomatic but sensitized and 31.8% were asymptomatic and not sensitized. When compared with children with non\u2010atopic eczema in the first 2 years of life, children with atopic eczema had a substantially greater risk of asthma [odds ratio (OR)=3.52, 95% confidence interval=1.88\u20136.59] and AR (OR=2.91, 1.48\u20135.71). The increased risk of asthma was even greater if the infant had a large SPT (OR=4.61, 2.34\u20139.09) indicative of food allergy. There was no strong evidence that children with non\u2010atopic eczema had an increased risk of asthma or AR compared with asymptomatic children.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> In children with eczema within the first 2 years of life, SPT can provide valuable information on the risk of childhood asthma and AR.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02822.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T12:50:09Z","timestamp":1192711809000},"page":"1624-1631","source":"Crossref","is-referenced-by-count":69,"title":["Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis"],"prefix":"10.1111","volume":"37","author":[{"given":"A. J.","family":"Lowe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Hosking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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