{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:23:27Z","timestamp":1789449807624,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,28]],"date-time":"2007-10-28T00:00:00Z","timestamp":1193529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    Traditional therapies for asthma and allergic rhinitis (AR) such as corticosteroids and antihistamines are not without limitations and side effects. The use of complementary and alternative approaches to treat allergic airways disease, including the use of herbal and dietary supplements, is increasing but their efficacy and safety are relatively understudied. Previously, we have demonstrated that \u03b3\u2010tocopherol (\u03b3T), the primary form of dietary vitamin E, is more effective than \u03b1\u2010tocopherol, the primary form found in supplements and tissue, in reducing systemic inflammation induced by non\u2010immunogenic stimuli.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    We used allergic Brown Norway rats to test the hypothesis that a dietary supplement with \u03b3T would protect from adverse nasal and pulmonary responses to airway allergen provocation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    Ovalbumin (OVA)\u2010sensitized Brown Norway rats were treated orally with \u03b3T before intranasal provocation with OVA. Twenty\u2010four hours after two challenges, histopathological changes in the nose, sinus and pulmonary airways were compared with gene expression and cytokine production in bronchoalveolar lavage fluid and plasma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    We found that acute dosing for 4 days with \u03b3T was sufficient to provide broad protection from inflammatory cell recruitment and epithelial cell alterations induced by allergen challenge. Eosinophil infiltration into airspaces and tissues of the lung, nose, sinus and nasolacrimal duct was blocked in allergic rats treated with \u03b3T. Pulmonary production of soluble mediators PGE\n                    <jats:sub>2<\/jats:sub>\n                    , LTB\n                    <jats:sub>4<\/jats:sub>\n                    and cysteinyl leukotrienes, and nasal expression of IL\u20104, \u20105, \u201013 and IFN\u2010\u03b3 were also inhibited by \u03b3T. Mucous cell metaplasia, the increase in the number of goblet cells and amounts of intraepithelial mucus storage, was induced by allergen in both pulmonary and nasal airways and decreased by treatment with \u03b3T.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    Acute treatment with \u03b3T inhibits important inflammatory pathways that underlie the pathogenesis of both AR and asthma. Supplementation with \u03b3T may be a novel complementary therapy for allergic airways disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02855.x","type":"journal-article","created":{"date-parts":[[2007,10,28]],"date-time":"2007-10-28T20:19:33Z","timestamp":1193602773000},"page":"501-511","source":"Crossref","is-referenced-by-count":67,"title":["\u03b3\u2010Tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma"],"prefix":"10.1111","volume":"38","author":[{"given":"J. G.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Harkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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