{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:59:08Z","timestamp":1776329948795,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,23]],"date-time":"2007-10-23T00:00:00Z","timestamp":1193097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The increase in the prevalence of allergic diseases in countries with a so\u2010called western lifestyle may be due to a decrease in exposure to infectious agents in early life.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To establish the effect of Bacille\u2013Calmette\u2013Guerin (BCG) vaccination in 6\u2010week\u2010old high\u2010risk infants in a prospective single\u2010blind, randomized, placebo\u2010controlled trial on the prevalence of allergic disease at the age of 4 and 18 months.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Subjects were 121 predominantly Caucasian high\u2010risk newborns, having either a mother, or both a father and at least one sibling with past or present allergic disease. BCG or placebo was administered at the age of 6 weeks, and repeated once when both a post\u2010vaccination scar and a positive TB skin test were absent at the age of 4 months.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> At the age of 18 months, the prevalence of allergic disease was not significantly different between the two groups. A trend towards less eczema (<jats:italic>P<\/jats:italic>=0.07) and significantly less use of medication for eczema was shown in the BCG group compared with the placebo group (<jats:italic>P<\/jats:italic>=0.04).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> A single (or once repeated) BCG vaccination in 6\u2010week\u2010old high\u2010risk Caucasian infants was not associated with a 50% reduction in the prevalence of allergic disease. However, there could be a smaller beneficial effect of BCG, especially because a trend towards less eczema and significantly less use of medication for eczema was shown. For definite proof, a larger study should be carried out.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02859.x","type":"journal-article","created":{"date-parts":[[2007,10,27]],"date-time":"2007-10-27T04:08:28Z","timestamp":1193458108000},"page":"79-85","source":"Crossref","is-referenced-by-count":79,"title":["Bacille\u2013Calmette\u2013Guerin vaccination and the development of allergic disease in children: a randomized, prospective, single\u2010blind study"],"prefix":"10.1111","volume":"38","author":[{"given":"T. J.","family":"Steenhuis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M. C.","family":"Van Aalderen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Bloksma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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