{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:27:05Z","timestamp":1759411625928},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T00:00:00Z","timestamp":1195430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Bacillus Calmette\u2010Gu\u00e9rin (BCG) vaccination triggers a T\u2010helper type 1 response. Whether BCG vaccination and positive tuberculin reactivity are preventive against allergic disorders remains controversial.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The current cross\u2010sectional study investigated the relationship of BCG vaccination and tuberculin reactivity with the prevalence of allergic disorders using data from the Ryukyus Child Health Study (RYUCHS).<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Subjects were 5717 schoolchildren aged 8\u201311 years in Okinawa, Japan. The RYUCHS collected information on symptoms of allergic disorders and potential confounding factors. The outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Data on BCG vaccination and tuberculin tests were obtained from school records. Allowance was made for grade, sex, sibship size, smoking in the household, paternal and maternal history of asthma, atopic eczema, and allergic rhinitis, and paternal and maternal educational level.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> No measurable relationship was found between BCG vaccination in infants and the prevalence of allergic disorders. Among 5567 BCG\u2010vaccinated children, positive tuberculin reactivity (induration 10\u2003mm) in the first grade was independently associated with a decreased prevalence of wheeze, asthma, and atopic eczema: the multivariate odds ratios for wheeze, asthma, and atopic eczema were 0.80 (95% confidence interval [CI], 0.67\u20130.94), 0.78 (95% CI, 0.64\u20130.95), and 0.77 (95% CI, 0.62\u20130.95), respectively. The inverse associations were more pronounced in children with a negative parental allergic history than in those with a positive parental allergic history. There was no significant relationship between tuberculin reactivity and allergic rhinoconjunctivitis.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> The findings suggest that positive tuberculin reactivity may be inversely associated with the prevalence of wheeze, asthma, and atopic eczema, but not allergic rhinoconjunctivitis, especially among Japanese children without a parental allergic history.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02869.x","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T02:28:27Z","timestamp":1195525707000},"page":"486-492","source":"Crossref","is-referenced-by-count":22,"title":["Tuberculin reactivity and allergic disorders in schoolchildren, Okinawa, Japan"],"prefix":"10.1111","volume":"38","author":[{"given":"Y.","family":"Miyake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,19]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"S2","article-title":"Family size, infection and atopy","volume":"55","author":"Strachan DP.","year":"2000","journal-title":"the first decade of the \u201chygiene hypothesis\u201d"},{"key":"e_1_2_6_3_2","first-page":"41","article-title":"Asthma","volume":"275","author":"Cookson WOCM","year":"1997","journal-title":"an epidemic in the absence of infection?"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4049\/jimmunol.158.4.1949","article-title":"Human T cell responses induced by vaccination with Mycobacterium bovis bacillus Calmette\u2010Gu\u00e9rin","volume":"158","author":"Ravn P","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.4049\/jimmunol.163.4.2249","article-title":"Newborns develop a Th1\u2010type immune response to Mycobacterium bovis bacillus Calmette\u2010Gu\u00e9rin vaccination","volume":"163","author":"Marchant A","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5296.77"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00803.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086461"},{"key":"e_1_2_6_9_2","first-page":"1126","article-title":"Immunization and symptoms of atopic disease in children","volume":"91","author":"Anderson HR","year":"2001","journal-title":"results from the International Study of Asthma and Allergies in Childhood"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02207-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03884.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00486.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.6.454"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.10.770"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1s3342.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1s3379.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.01006.x"},{"key":"e_1_2_6_18_2","first-page":"541","article-title":"The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years","volume":"111","author":"Marks GB","year":"2003","journal-title":"an historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00517.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00557.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.57.s73.49_4.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_6_23_2","first-page":"315","article-title":"Worldwide variations in the prevalence of asthma symptoms","volume":"12","author":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee.","year":"1998","journal-title":"the International Study of Asthma and Allergies in Childhood (ISAAC)"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70536-1"},{"key":"e_1_2_6_25_2","first-page":"161","article-title":"Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children","volume":"8","author":"Strachan DP","year":"1997","journal-title":"the International Study of Asthma and Allergies in Childhood (ISAAC)"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61021-6"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062206"},{"key":"e_1_2_6_28_2","first-page":"844","article-title":"T cell activation, from atopy to asthma","volume":"58","author":"El Biaze M","year":"2003","journal-title":"more a paradox than a paradigm"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.t01-1-01607.x"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2007.02869.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2007.02869.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:01:41Z","timestamp":1697234501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2007.02869.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,19]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1365-2222.2007.02869.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2007.02869.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,19]]}}}