{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:36:06Z","timestamp":1781199366558,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Increasing interest has arisen whether helminthic infections protect against asthma and allergy. The prevalence of wheezing among Bangladeshi children is higher in rural areas where helminthic infectious burden is greater, which is contrary to the general assumption.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We therefore examined the association between <jats:italic>Ascaris<\/jats:italic> infection, serum level of anti\u2010<jats:italic>Ascaris<\/jats:italic> IgE, which should be investigated differently from the infection, and wheezing in 5\u2010year\u2010old children from rural Bangladesh.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> A total of 219 children who reported wheezing during the previous 12 months and 122 randomly selected age\u2010matched individuals who had never experienced wheezing were tested for serum levels of total and specific <jats:italic>Ascaris<\/jats:italic>, <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>, <jats:italic>alternaria<\/jats:italic> and cockroach IgEs, and for intestinal helminth infection as well.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Anti\u2010<jats:italic>Ascaris<\/jats:italic> IgE levels were significantly and independently associated with current wheezing during the previous 12 months [odds ratio (OR) per log<jats:sub>e<\/jats:sub> increment is 1.31 (95% confidence interval (CI) 1.08\u20131.60), <jats:italic>P<\/jats:italic>=0.007], a history of at least four episodes of wheezing [OR per log<jats:sub>e<\/jats:sub> increment is 1.52 (95% CI 1.18\u20131.96), <jats:italic>P<\/jats:italic>=0.001], wheezing with sleep disturbances [OR per log<jats:sub>e<\/jats:sub> increment is 1.35 (95% CI 1.10\u20131.64), <jats:italic>P<\/jats:italic>=0.011] and wheezing with speech disturbances [OR per log<jats:sub>e<\/jats:sub> increment is 1.57 (95% CI 1.19\u20132.08), <jats:italic>P<\/jats:italic>=0.001]. These were adjusted for gender, pneumonia history, parental asthma, <jats:italic>Trichuris<\/jats:italic> infection, use of dry leaves as fuel and other specific IgE levels. The prevalence of <jats:italic>Ascaris<\/jats:italic> infection by the presence of wheezing was not significantly different (76% vs. 72%, respectively).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> We conclude that a high titre of anti\u2010<jats:italic>Ascaris<\/jats:italic> IgE is associated with an increased risk of asthma symptoms among 5\u2010year\u2010old rural Bangladeshi children with a high helminthic infectious load.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02890.x","type":"journal-article","created":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T23:28:32Z","timestamp":1280791712000},"page":"276-282","source":"Crossref","is-referenced-by-count":45,"title":["High titre of anti\u2010<i>Ascaris<\/i> immunoglobulin E associated with bronchial asthma symptoms in 5\u2010year\u2010old rural Bangladeshi children"],"prefix":"10.1111","volume":"38","author":[{"given":"H.","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yunus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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